Searchable abstracts of presentations at key conferences in endocrinology

ea0029p202 | Calcium & Vitamin D metabolism | ICEECE2012

Vitamin D pathway in non-functioning pituitary adenomas

Vuolo L. , Di Somma C. , Negri A. , Pivonello C. , Savanelli M. , Faggiano A. , Guerra E. , Pivonello R. , Colao A.

Introduction: In addition to its well known effects on calcium homeostasis and bone metabolism, growing evidences shows that vitamin D plays an important role in regulation of cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Vitamin D acts through vitamin D receptor (VDR), an intracellular nuclear receptor. It was found an association between different cancer histotypes and single nucleotide polymorphisms (SNPs) of VDR. Despite the close relationship be...

ea0029p781 | Endocrine tumours and neoplasia | ICEECE2012

Hepatocellular carcinoma (HCC) as a neuroendocrine tumor: a preliminar molecular study.

Pivonello C. , Vitale G. , Izzo F. , Di Sarno A. , Giorgio A. , Hofland L. , Colao A. , Pivonello R.

Hepatocellular carcinoma (HCC) is often diagnosed at late stage or metastatic condition. Surgical resection is considered treatment of choice and other treatment options include chemoembolization, radiofrequency ablation and photodynamic therapy. We evaluated the expression levels of the 5 somatostatin receptors (SSTRs) in 23 biopsies of HCC patients and also mTOR, p70S6K and 4eBP1 in HuH-7 and HepG2 and investigated the in vitro effect of somatostatin analogs (SA) and ...

ea0026p75 | Endocrine tumours and neoplasia | ECE2011

T-type calcium channel blockers inhibit hormone secretion and induce apoptotic cell death in a medullary thyroid cancer cell line

Pivonello R , Pivonello C , Cavaccini A , Sarnataro M , Cariati F , Faggiano A , Colao A , Cataldi M

Medullary thyroid carcinoma (MTC) accounts for ~5–10% of thyroid cancers. Intense efforts are currently directed toward the identification of new druggable targets for the treatment of MTC. The aim of this study was to investigate whether drugs acting at voltage-gated T-type calcium channels could affect hormone release and/or cell proliferation in a MTC cell line, the TT cells. The expression of the three isoforms of T-type calcium channels (CaV3.1, CaV3.2 and CaV3.3) wa...

ea0029p132 | Bone & Osteoporosis | ICEECE2012

Osteoporosis and vitamin D deficiency in patients with lipid storage disease

Del Prete M. , Negri A. , Sarnataro M. , Pivonello C. , Ramundo V. , Marotta V. , Russo R. , Carratu A. , Cianciaruso B. , Colao A. , Pisani A. , Faggiano A.

Introduction: Bone metabolism is impaired in several lipid storage diseases. At now no data are available in Fabry disease (FD), a genetic lipid storage disease characterized by systemic accumulation of glicolipids. The aim of this study was to evaluate bone metabolism and calcium/vitamin-D pathway in patients with FD.Methods/design: Study population included 15 FD patients (8 M and 7 F, age 28–59 years) and 15 sex-, age- and BMI-matched normal subj...

ea0029p836 | Endocrine tumours and neoplasia | ICEECE2012

Vitamin D from genetics to the clinical in prostate cancer

Cariati F. , Negri A. , Pivonello C. , Ferro M. , Sarnataro M. , Terracciano D. , Galdiero M. , Vitale P. , Altieri V. , Colao A. , Pivonello R.

Background: The prostate cancer (CaP) is among the most commonly diagnosed cancers, accounting for about 20% of all newly diagnosed cancers. Subject of recent studies is the role of vitamin D in the pathogenesis of CaP. Literature data speculated about the role of vitamin D in the progression of Cap. In addition, several studies have shown an association between VDR gene polymorphism FokI and CaP especially in the Asian population.Objective: The aim of t...

ea0026p257 | Pituitary | ECE2011

Fertility rate in acromegalic women: a single center experience on 70 patients before and after treatment

Grasso L F S , Galdiero M , Auriemma R S , Cozzolino A , Vitale P , Simeoli C , Pivonello R , Colao A

Women with acromegaly present often menstrual irregularity, anovularity and infertility. A direct role of GH and IGF1 excess on the hypothalamus–pituitary–gonadal axis, hyperprolactinemia and an impaired gonadotrophin secretion related to a tumor mass effect, or polycystic ovary syndrome have been suggested as possible mechanisms related to infertility. However, no systematic data are available on fertility in these patients. The aim of this retrospective study was t...