Searchable abstracts of presentations at key conferences in endocrinology

ea0099rc9.6 | Rapid Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Prevalence and determinants of microvascular and macrovascular complications of diabetes in acromegaly patients: A prospective case-control cross-sectional study

Pirchio Rosa , Auriemma Renata Simona , Scairati Roberta , Tropiano Antonella , De Simone Ivan , Vergura Alice , Del Vecchio Guendalina , Pivonello Claudia , Pivonello Rosario , Colao Annamaria

Context: Although diabetes mellitus is a major complication in patients with acromegaly, prevalence and determinants of microvascular and macrovascular complications of diabetes remains unexplored in this population.Aim: To investigate prevalence and determinants of microvascular and macrovascular complications in acromegaly patients with diabetes and to compare them with a group of diabetic patients without acromegaly.Methods: Pro...

ea0099ep269 | Pituitary and Neuroendocrinology | ECE2024

Disentangling glucose metabolism during and after pregnancy in women with chronic hyperprolactinemia

Roberta Scairati , Simona Auriemma Renata , Di Meglio Sara , Del Vecchio Guendalina , Pirchio Rosa , Graziadio Chiara , Pivonello Claudia , Pivonello Rosario , Colao Annamaria

Context: Prolactin (PRL) exerts a crucial role in the regulation of mammalian reproduction and in the promotion of lactation as response to the suckling reflex. Beyond this, it directly modulates gluco-insulinemic metabolism.ObjectiveTo dissect glucose metabolism during and after pregnancy in patients with chronic hyperprolactinemia (CTPE).MethodsThis longitudinal study included 52 reproductive aged women with CTPE due to pituitary adenomas (43 microadenomas, 9 macroadenomas),...

ea0041gp230 | Thyroid Cancer (1) | ECE2016

Analysis of germline VEGF-A SNPs allows the identification of a subgroup of ATA low-intermediate risk DTC (differentiated thyroid cancer) patients with poor probability to develop recurrences

Marotta Vincenzo , Sciammarella Concetta , Capasso Mario , Testori Alessandro , Gambardella Claudio , Grasso Marica , Rubino Manila , De Palma Maurizio , Grazia Chiofalo Maria , Pivonello Claudia , Pivonello Rosario , Santini Luigi , Pezzullo Luciano , Colao Annamaria , Faggiano Antongiulio

Introduction: Constitution of new blood vessels is crucial for cancer self-maintenance and progression. Neo-angiogenesis may be affected from hereditary traits, namely the presence of SNPs (single nucleotide polymorphisms) of genes involved in its regulation. VEGF-A represents the main regulator of angiogenesis. Germline SNPs of the VEGF-A gene have been associated to outcome of several cancers, but no data exist about differentiated thyroid cancer (DTC).<p class="abstext"...

ea0099p318 | Pituitary and Neuroendocrinology | ECE2024

Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-levels analysis from a multicenter clinical trial

Hasenmajer Valeria , Sbardella Emilia , Sciarra Francesca , Rizzo Flavio , Simeoli Chiara , Pivonello Claudia , Pivonello Rosario , Ceccato Filippo , Scaroni Carla , Arnaldi Giorgio , Pofi Riccardo , Cozzolino Alessia , Minnetti Marianna , Alunni Fegatelli Danilo , Conia Simone , Navigli Roberto , Gianfrilli Daniele , Anna Venneri Mary , Isidori Andrea

Background: Glucocorticoids (GC) are potent entrainers of the circadian clock, however their effect on biological rhythms in human chronic exposure have been poorly studied. Endogenous hypercortisolism (CushingÂ’s Syndrome, CS) is a rare condition, in which circadian disruption is sustained by a tumorous source of GC excess, offering the unique opportunity to investigate the in vivo chronic effects of GC.Methods: In a 12-month prospective mu...

ea0022p49 | Adrenal | ECE2010

In vitro effect of dopastatins on hormone secretion in adrenal tumors

Pivonello Claudia , Napolitano Tiziana , De Leo Monica , Cozzolino Alessia , Vitale Pasquale , Lombardi Gaetano , Colao Annamaria , Pivonello Rosario

Somatostatin (SSTRs) and dopamine (DRs) receptors are expressed in adrenal tumors. It has been demonstrated in pituitary and neuroendocrine tumors that somatostatin-dopamine chimeric molecules, namely dopastatins, which bind both somatostatin (SST2 and/or SST5) and dopamine (D2) receptors, exert a more potent action compared with the single receptor agonists in experimental settings. The aims of this study were to evaluate the expression of DRs and SSTRs, and the effects of do...

ea0081p532 | Adrenal and Cardiovascular Endocrinology | ECE2022

Covid-19 in patients with hypocortisolism: clinical syndrome, disease duration and glucocorticoid replacement therapy

Simeoli Chiara , Schettino Serafina , La Rocca Angelica , Di Paola Nicola , Massimo Crescenzo Erminio , Ciardella Francesco , Mazzarella Alessandro , Pivonello Claudia , Colao Annamaria , Pivonello Rosario

Coronavirus disease caused by SARS-CoV-2 virus (Covid-19) is associated with a variable clinical syndrome, ranging from a mild-moderate to a severe disease, progressing towards acute respiratory distress syndrome. Hypocortisolism is associated with a depletion of innate immunity and disruption of immune response, which could contribute to an increased risk of infection and development of a severe disease. Glucocorticoid (GC) replacement therapy(GCRT), especially if administere...

ea0081p64 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The bidirectional relationship between testosterone and metabolic disorders: testosterone deficiency as an early marker of cardiovascular risk in young men

Menafra Davide , De Angelis Cristina , Garifalos Francesco , Castoro Michele , Verde Nunzia , Piscopo Mariangela , Galdiero Giacomo , Pivonello Claudia , Simona Auriemma Renata , Chiodini Paolo , Colao Annamaria , Pivonello Rosario

In the last years an increasing incidence of cardiovascular diseases (CVD) has been reported in young adults (18-45 yrs), probably accounted by the significant increase in CV risk (CVR) factors. Observational and interventional studies, mainly focused on middle-aged and elderly men, demonstrated that metabolic CVR (mCVR) factors and CVD manifestations are common in hypogonadal men and, conversely, testosterone deficiency is highly prevalent in metabolic disorders; the lack of ...

ea0081p614 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Dopaminergic system and adipose tissue: in vitro effect of cabergoline on white, brown and beige adipogenesis and lipogenesis processes

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Angelis Cristina de , Simeoli Chiara , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Adipose tissue is an endocrine organ releasing adipokines and expressing specific markers and intracellular mediators, which regulate whole-body energy by balancing lipid accumulation and utilization through adipogenesis, the differentiation of preadipocytes into mature adipocytes associated with gradual lipid storage, and lipogenesis, the additional lipid accumulation in mature adipocytes. Adipogenesis and lipogenesis, strongly induced by insulin, occur in white adipocytes, s...

ea0090p330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cabergoline counteracts adipose and skeletal muscle lipid accumulation through promoting oxidative pathway: an in vivo and in vitro preclinical study

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Paola Provvisiero Donatella , Simeoli Chiara , de Angelis Cristina , Simona Auriemma Renata , Colao Annamaria , Crescenzo Raffaella , Pivonello Rosario

Obesity, characterized by an abnormal body fat accumulation mainly caused by a chronic imbalance between energy intake and expenditure, is a massive public health problem. Targeting excessive fat deposition in adipose tissue and ectopic fat accumulation in skeletal muscle through promoting lipid oxidation pathway may represent a promising strategy to counteract obesity. This study aims at investigating the effects of cabergoline (CAB), a dopamine agonist, on adipose and skelet...

ea0090p145 | Pituitary and Neuroendocrinology | ECE2023

Somatostatin receptor type 2 (SSTR2) expression regulation by miR-375 in a murine pituitary corticotroph tumor cell model

Pivonello Claudia , Patalano Roberta , Monto Tatiana , Negri Mariarosaria , Amatrudo Feliciana , Paola Provvisiero Donatella , Simeoli Chiara , Paola Nicola , Larocca Angelica , Massimo Crescenzo Erminio , Colao Annamaria , Pivonello Rosario

CushingÂ’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of hypercortisolism. Pituitary surgery is the first-line treatment of CD and medical treatment is an alternative second-line approach to control cortisol excess. Long-term exposure to glucocorticoids (GC) downregulates the expression of somatostatin receptor type 2 (SSTR2) but not type 5 (SSTR5) in human and mouse ACTH-secreting tumor cell cultures; t...