Endocrine Abstracts

Introduction: Mutation in PROP1 gene is the cause of different forms of pituitary dysfunction. The assessment of the functioning of the adrenal axis still raises the most doubts.Aim& methods: A retrospective longitudinal (mean 35 years, SD 16.24) analysis of 32 patients (19W/13M, including 5 families and sporadic cases) with PROP1 mutation was performed to define the optimal diagnostic approach in evaluation of adrenal axis. In the study morning cort...

Introduction: The mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood. The function of adrenal axis requires special attention.Aim: To investigate the time/mode/markers of pituitary function deterioration in families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed retrospective longitudinal (36.4 years, s.d. = 13.6) analy...