Searchable abstracts of presentations at key conferences in endocrinology

ea0090p725 | Reproductive and Developmental Endocrinology | ECE2023

The Role of Testosterone Treatment in Patients with Type 2 Diabetes Mellitus: Results from A Meta-Analysis Study

Vena Walter , Vignozzi Linda , Maggi Mario , Sforza Alessaandra , Pizzocaro Alessandro , Corona Giovanni

Introduction: type 2 diabetes mellitus (T2DM) and hypogonadism are common conditions afflicting the aging male, often present together. The specific role of testosterone (T) replacement therapy (TRT) on glycometabolic profile and body composition, particularly in patients with T2DM, is still the object of an intense debate. The aim of the present study is to meta-analyze the role of TRT in T2DM considering all placebo and non-placebo-controlled randomized clinical trials (RCTs...

ea0056gp18 | Adrenal Case reports | ECE2018

Bilateral testicular masses and adrenal insufficiency in a young adult: is congenital adrenal hyperplasia the only possible diagnosis?

Tresoldi Alberto Stefano , Betella Nazarena , Pizzocaro Alessandro , Lania Andrea Gerardo Antonio

Testicular adrenal rest tumours (TARTs) are benign tumours deemed to originate from ectopic adrenal cells that descend with the testes during fetal development. These cells grow under chronic ACTH stimulation, typically in patients with congenital adrenal hyperplasia (CAH). TARTs have also been rarely described in other conditions characterised by chronically elevated ACTH, such as autoimmune primary adrenal insufficiency (PAI). These are benign lesions, but could be misdiagno...

ea0081p709 | Reproductive and Developmental Endocrinology | ECE2022

Serum testosterone mirrors inflammation parameteres in females admitted with covid-19 disease

Francesca Birtolo Maria , Vena Walter , Pizzocaro Alessandro , Jaafar Simona , Ciafardini Antea , Brunetti Alessandro , Pigni Stella , Mazziotti Gherardo , Lania Andrea

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is showing a rapid and continuous evolution in terms of new waves, the spread of variants and the evidence of reinfections. The growing heterogeneity of clinical presentation requires the identification of underlying pathogenic mechanisms to allow a better risk stratification. Previous studies analysed the role of sex hormones in disease severity demonstrating in male patients the association of...

ea0081p299 | Calcium and Bone | ECE2022

Impact of body composition on skeletal health in subjects with Klinefelter’s syndrome: a cross sectional study

Carrone Flaminia , Vena Walter , Delbarba Andrea , Chiara Pezzaioli Letizia , Facondo Paolo , Cappelli Carlo , Pizzocaro Alessandro , Mazziotti Gherardo , Lania Andrea Gerardo , Ferlin Alberto

Background: There is growing awareness of skeletal impairment in individuals with Klinefelter syndrome (KS), involving both quantitative and qualitative alteration of the bone as well as an increased prevalence of vertebral fractures (VFs). Beyond hypogonadism, considerable evidence suggests that other factors may be responsible for the skeletal fragility observed in these patients. Abnormal body composition is a common finding in KS subjects, characterized by an unfavourable ...

ea0081p309 | Calcium and Bone | ECE2022

Testosterone supplementation and bone parameters, a systematic review and meta-analysis study

Vena Walter , Corona Giovanni , Pizzocaro Alessandro , Giagulli Vito , Francomano Davide , Rastrelli Giulia , Aversa Antonio , Marcello Isidori Andrea , Pivonello Rosario , Vignozzi Linda , Mannucci Edoardo , Maggi Mario , Ferlin Alberto

Background: Testosterone (T) is essential for bone health during all ages, helping to achieve a proper peak bone mass and, later, to maintain bone density and strength. Guidelines on management of male osteoporosis recommend testosterone replacement in young-adult hypogonadal to prevent bone loss and anti-resorbitive drugs in case of high fracture risk, but the role of T replacement therapy (TRT) alone in subjects with late onset hypogonadism is still the object of an intense ...

ea0063gp65 | Reproductive Axis | ECE2019

Testosterone replacement therapy outcomes in subjects with Klinefelter syndrome: preliminary results from a meta-analysis study

Vena Walter , Pizzocaro Alessandro , Pelliccione Fiore , Pivonello Rosario , Radicioni Antonio , Selice Riccardo , Rastrelli Giulia , Pasquali Daniela , Calogero Aldo Eugenio , Ferlin Alberto , Francavilla Sandro , Garolla Andrea , Corona Giovanni

Background: In patients with Klinefelter syndrome (KS) morbidity and mortality seem to be higher than general population, this depending on a wide number of possible comorbidities. Impaired metabolic profile, increased risk of venous thrombosis and the consequent increase of cardiovascular diseases might play a key role in this condition as well as reduced bone mineral density and higher fracture risk. Nowadays testosterone replacement therapy (TRT) is the first-choice treatme...

ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

ea0070aep779 | Reproductive and Developmental Endocrinology | ECE2020

Coagulation abnormalities in patients with klinefelter syndrome compared to age-matched healthy controls: Cross-sectional assessment by thrombin generation test

Indirli Rita , Profka Eriselda , Vena Walter , Cangiano Biagio , Pizzocaro Alessandro , Bonomi Marco , Clerici Marigrazia , Scalambrino Erica , Mazziotti Gherardo , Lania Andrea , Arosio Maura , Mantovani Giovanna , Tripodi Armando , Ferrante Emanuele

Introduction: Klinefelter syndrome (KS) is known to be associated with an increased risk of venous thromboembolism and arterial thrombosis, but the aetiology behind this prothrombotic status has not been fully elucidated. The aim of this study was to cross-sectionally investigate the coagulative state in subjects with KS compared to age-matched healthy males.Methods: Coagulation factors assessment, clinical characteristics collection and thrombin generat...

ea0075r06 | Reproductive Endocrinology | EYES2021

Low testosterone is a predictor of hypoxemic respiratory insufficiency and higher mortality rate in SARS-CoV-2 hospitalized patients: A cohort study

Vena Walter , Pizzocaro Alessandro , Maida Giulia , Amer Myriam , Voza Antonio , Di Pasquale Andrea , Reggiani Francesco , Ciccarelli Michele , Fedeli Carlo , Lavezzi Elisabetta , Mazziotti Gherardo , Lania Andrea

Objective: To evaluate the association between testosterone (T) values and clinical outcome of COVID-19.Methods: This is a retrospective single-center study performed on 221 male patients (median age 70.5 years, range 26-93) with COVID-19 and hospitalized in our Institution between November 1st 2020 and January 31st 2021. PatientsÂ’ height, weight, BMI, medical history and comorbidities were recorded; at admission, patients underwent sampling for com...

ea0081p695 | Reproductive and Developmental Endocrinology | ECE2022

Andrological effects of SARS-Cov2 infection: a systematic review and meta-analysis

Vena Walter , Corona Giovanni , Pizzocaro Alessandro , Pallotti Francesco , Paoli Donatella , Rastrelli Giulia , Baldi Elisabetta , Cilloni Nicola , Semeraro Federico , Salonia Andrea , Minhas Suks , Pivonello Rosario , Sforza Alessandra , Vignozzi Linda , Marcello Isidori Andrea , Lenzi Andrea , Maggi Mario , Lombardo Francesco

Background: Since the preliminary epidemiological data concerning the coronavirus disease 2019 (COVID-19) has been availabe, clear sex disparity has been evident, with males, although not more frequently affected, often experiencing worse outcomes when compared to women. The short and long term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. The aim of the present study is to systematically review and meta-analyze all available data regardi...