Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1109 | Thyroid Cancer | ECE2014

Ca 19-9: is there a role for potential new biomarker for medullary thyroid cancer?

Katalinic Darko , Santek Fedor , Juretic Antonio , Stern-Padovan Ranka , Nikolac Nora , Grah Josip Joachim , Plestina Stjepko

In the recent years, knowledge about cancer biomarkers has increased tremendously providing great opportunities for improving the diagnosis, prognosis and treatment of cancer patients. In clinical practice, the levels of serum calcitonin, and carcinoembryonic antigen (CEA) are important during follow-up for patients with medullary thyroid cancer (MTC). Carbohydrate antigen 19-9 (CA 19-9), routinely used in the monitoring of pancreatic, hepatobiliary, and colon carcinoma, also ...

ea0022p282 | Diabetes | ECE2010

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene (IRS1) and the impact on type 2 diabetes mellitus

Katalinic Darko , Nikolac Nora , Zjacic-Rotkvic Vanja , Topic Elizabeta , Solter Miljenko , Plestina Stjepko

Background: Genetics may play an important role in type 2 diabetes (T2D). In the last 20 years, there has been a surge in the number of genetic studies in attempts to identify some of the underlying risk factors. Mutations in a wide variety of genes contribute to the deregulation of glucose homeostasis, and seem to confer the risk for developing T2D. Insulin receptor substrate-1 (IRS1) is a substrate of the insulin receptor tyrosine kinase and appears to have a control role in...

ea0022p283 | Diabetes | ECE2010

Impact of the SUR1 16-3 C/T and INSR His 1085 C/T genetic variability on type 2 diabetes mellitus development

Katalinic Darko , Nikolac Nora , Zjacic-Rotkvic Vanja , Topic Elizabeta , Solter Miljenko , Plestina Stjepko

Background: Type 2 diabetes (T2D), which is multifactorial, inherited and progressive chronic disorder, is characterised by hyperglycemia due to defects in insulin secretion and action. The sulfonylurea receptor (SUR1) and the insulin receptor (INSR) are critical elements in insulin-signalling pathways, and mutations in the SUR1 and INSR genes have been reported to have a role in determining susceptibility to T2D.The aim was to study whether the -3 C/T p...

ea0032p749 | Obesity | ECE2013

BMI as a prognostic feature in patients with breast cancer treated with chemo/endocrine therapy

Katalinic Darko , Santek Fedor , Juretic Antonio , Basic-Koretic Martina , Loncar Kresimir , Soce Majana , Nikolac Nora , Plestina Stjepko

Introduction: High BMI has been associated with an increased risk for breast cancer among premenopausal and postmenopausal women. Several biological mechanisms play a significant role in the genesis and progression of breast cancer.Material and methods: This study aimed to investigate relationship between BMI and breast cancer diagnosis or progression in a Croatian population. BMI, presence or absence of breast cancer and its clinical-pathological charac...