Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep797 | Reproductive and Developmental Endocrinology | ECE2020

Ovarian reserve and serum concentration of thyroid peroxidase antibodies in euthyroid women with different polycystic ovary syndrome phenotypes

Adamska Agnieszka , Lebkowska Agnieszka , Krentowska Anna , Pliszka Justyna , Adamski Marcin , Leśniewska Monika , Kowalska Irina

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

ea0035p392 | Diabetes (epidemiology, pathophysiology) | ECE2014

Resistin mRNA expression in fat and placental tissue of patients with gestational diabetes

Szamatowicz Michal , Wawrusiewicz-Kurylonek Natalia , Kuzmicki Mariusz , Telejko Beata , Wilk Juliusz , Pliszka Justyna , Lipinska Danuta , Szamatowicz Jacek , Kretowski Adam , Gorska Maria

Introduction: Resistin is a cysteine–rich adipokine that was originally described as a molecular link between obesity and insulin resistance. Our previous study showed higher serum resistin levels in patients with gestational diabetes mellitus (GDM) in comparison with healthy pregnant women however conflicting results have been reported by other authors. Therefore in the present study we investigated whether there were significant differences in resistin mRNA expression i...

ea0035p776 | Obesity | ECE2014

Application of LC–MS and CE–MS based metabolomics to study type 2 diabetes development in lean, overweight and obese humans

Ciborowski Michal , Kretowski Adam , Adamska Edyta , Citko Anna , Waszczeniuk Magdalena , Wilk Juliusz , Golonko Anna , Pliszka Justyna , Lipinska Danuta , Goscik Joanna , Rusak Magdalena , Godzien Joanna , Barbas Coral , Gorska Maria

The risk of type 2 diabetes mellitus (T2DM) development is related to BMI, therefore this disease mainly occurs among overweight (OW) and obese (OB) people. However lean (L) individuals may also suffer from T2DM. The evolution of T2DM is a multistep process and starts with insulin resistance (IR), which may evolve into pre-diabetic state i.e.: impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In up to 70% of patients pre-diabetic state evolves into T2DM. ...

ea0032p360 | Diabetes | ECE2013

TCF7L2 gene polymorphisms may influence insulin sensitivity and leptin levels independently from BMI and body fat content

Kretowski Adam , Adamska Edyta , Wawrusiewicz-Kurylonek Natalia , Citko Anna , Goscik Joanna , Maliszewska Katarzyna , Wilk Juliusz , Waszczeniuk Magdalena , Lipinska Danuta , Pliszka Justyna , Ciborowski Michal , Gorska Maria

Introduction: The genome-wide association studies have recently expanded the number of genetic susceptibility loci for type 2 diabetes and obesity. Transcription factor 7-like 2 (TCF7L2) gene seems to be one of the most predictive identifiable factors promoting T2DM development. It has been suggested that TCF7L2 influences pancreatic β-cell function butthe effect of genetic variants of TCF7L2 on metabolic syndrome development is not well characterized among subje...