Searchable abstracts of presentations at key conferences in endocrinology

ea0011s73 | Endocrine oncogenesis and management of hereditary endocrine tumours | ECE2006

Familial phaeochromocytomas

Plouin PF

Phaeochromocytomas are catecholamine-secreting tumors that usually arise from the adrenal medulla. Catecholamine-secreting tumors may also develop in retroperitoneal, pelvic or thoracic paraganglia. Here, we use the term phaeochromocytoma for catecholamine-secreting adrenal or extra-adrenal tumors. Before 2000, 10 to 15% of the patients with phaeochromocytoma were reported to have family or phenotypic evidence of a hereditary disease: multiple endocrine neoplasia type 2 (MEN2;...

ea0011p489 | Endocrine tumours and neoplasia | ECE2006

Evaluation of a standardized protocol for the collection and storage of adrenal tumor samples – preparation for an European adrenal tumor bank (ENS@T)

Johnsen I , Hahner S , Fassnacht M , Bertherat J , Bertagna X , Plouin PF , Reincke M , Allolio B , Beuschlein F

Tissue samples from adrenal tumors provide the basis for standard diagnostic procedures such as pathological examination. In addition, these tumor samples have been an invaluable source for the discovery of novel molecular pathways involved in adrenal tumorigenesis. Information on the molecular phenotype are based on DNA mutation analysis and epigenetic changes, RNA and protein expression pattern and sub-cellular localization as well as post transcriptional protein modificatio...