Searchable abstracts of presentations at key conferences in endocrinology

ea0015p221 | Pituitary | SFEBES2008

Gamma knife radiosurgery: a safe and effective treatment for acromegaly

Swords FM , Monson JP , Besser GM , Chew SL , Drake WM , Grossman AB , Plowman PN

We report the use of Gamma knife radiosurgery (GK) to 15 somatotroph adenomas. Eight patients had refractory acromegaly despite maximal conventional treatments: all had undergone conventional radiotherapy (CRT), mean interval between CRT and GK 15.6 years. Six had undergone surgery, two on more than one occasion. Five were receiving somatostatin analog therapy, one was receiving dopamine agonist therapy, one was on pegvisomant alone. All had radiologically defined disease, wel...

ea0012p11 | Clinical case reports/Governance | SFE2006

Sporadic pancreatic somatostatinomas: 3 cases

Brooke AM , Cheung TT , Metcalfe K , Carlsen E , Berney D , Bhattacharya S , Plowman PN , Monson JP , Drake WM

Sporadic somatostatinomas are rare neuroendocrine tumours (NETs), classically presenting with hyperglycaemia, cholelithiasis and steatorrhoea. The mainstay of treatment is surgical resection; other aspects of management remain uncertain. We report 3 cases. Case 1: A 55 year-old female presented with abdominal discomfort and steatorrhoea. Computed tomography (CT) demonstrated a 9 cm pancreatic mass. Biopsy suggested a NET. Somatostatin (SMS) was 160 pmol/l (normal 0-150)...

ea0017p23 | (1) | BSPED2008

Prepubertal Cushing's disease: diagnosis and therapeutic outcome

Kumaran A , Chan LF , Martin L , Afshar F , Matson M , Plowman PN , Monsoon JP , Besser GM , Grossman AB , Savage MO , Storr HL

Cushing’s disease (CD) is very rare in prepubertal children, and remains a challenge to diagnose and manage. We review the diagnostic features and therapeutic outcome of prepubertal (defined as testicular volume <4 ml (M) and breast stage <2 (F)) CD patients treated in a single centre. Fifteen prepubertal patients (median age 9.4 years; range 5.8–13.7) fulfilled standard diagnostic criteria for CD and there was male preponderance (12 M (80%), median age 9.1 y...