Searchable abstracts of presentations at key conferences in endocrinology

ea0056p47 | Adrenal cortex (to include Cushing's) | ECE2018

The renin-angiotensin-aldosteron system in primary adrenal insufficiency

Wolf Peter , Mayr Johanna , Poglitsch Marko , Gessl Alois , Luger Anton , Winhofer Yvonne , Krebs Michael

Background: Despite adequate hormone replacement therapy, evidence suggests that mortality is increased in patients suffering from primary adrenal insufficiency (AI), mainly because of cardiovascular diseases. Since activation of the renin-angiotensin-aldosteron system (RAAS) plays an important role in the development of hypertension and cardiovascular disease we aimed to investigate, if there are differences in AI compared to healthy controls.Methods: E...

ea0063gp133 | Obesity | ECE2019

Effect of IL1-receptor antagonist on renin-angiotensin-aldosterone system and hemodynamics in obese individuals

Urwyler Sandrine , Ebrahimi Fahim , Burkard Thilo , Schuetz Philipp , Poglitsch Marko , Beat Mueller , Donath Marc Y , Christ-Crain Mirjam

Background: Interleukin (IL)-1 antagonism decreases systolic blood pressure in obese individuals. However, the underlying mechanism is unknown. Based on experimental data in animals we hypothesised a blood-pressure lowering effect of IL-1-antagonism via modulation of the renin-angiotensin-aldosterone system (RAAS).Methods: In this post-hoc explorative study, we examined short- (2 days) and long-term effects (4 weeks) of IL-1 antagonism (anakinra/Kineret<...

ea0049gp2 | Adrenal 1 | ECE2017

Contribution of retinoic acid receptor signalling to adrenal cortex morphology and functional zonation through modulation of WNT/β-catenin pathway

El Zein Rami , Rickard Amanda J , Felipe Golib Dzib Jose , Samson-Couterie Benoit , Rocha Angelique , Poglitsch Marko , Gomez-Sanchez Celso E , Amar Laurence , Fernandes-Rosa Fabio Luiz , Ghyselinck Norbert B , Benecke Arndt , Lalli Enzo , Zennaro Maria-Christina , Boulkroun Sheerazed

Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 have been identified in aldosterone producing adenoma (APA). Although the role of these mutations in regulating aldosterone biosynthesis has been clearly established, the mechanisms involved in proliferation and APA formation still remain to be elucidated. The aim of our study was to identify pathways involved in adrenal cortex nodulation and APA formation.Transcriptomic a...