Searchable abstracts of presentations at key conferences in endocrinology

ea0029s37.3 | Diabetes and cancer | ICEECE2012

Goiter throughout the pediatric ages

Polak M.

Goiter may be present before birth in utero, at birth or detected at any age thereafter. The goiter may be caused by increased thyrotropin (TSH) secretion resulting from hypothyroidism; antibodies that activate TSH receptors (GravesÂ’ disease) with increased thyroid hormone secretion; or TSH-independent processes, such as inflammation associated with autoimmune thyroiditis, benign and malignant tumors, and infiltrative disease.The causes of goiter in...

ea0029p496 | Developmental endocrinology | ICEECE2012

Evaluation of cognitive, affective and relational skills of adolescents treated with testosterone for 47XXY klinefelter syndrome

Lubienski A. , Gueniche K. , Polak M.

The early diagnosis of 47XXY- Klinefelter syndrome (KS) associated with infertility confronts the parents with concerns about their child outcome on cognitive, social skills and sexual identity. Few studies relate the weakness of intelligence, mainly verbal, and relational inhibition. Androgen may be offered to adolescents to normalize anatomic and psychic puberty processes. This has never been evaluated in psychological terms.Subjects and methods: Eight...

ea0029p898 | Female Reproduction | ICEECE2012

State of care in women affected by early premature ovarian failure (ePOF) within the first two years of treatment in a center for reproductive medicine and endocrinology (RME)

Benabbad I. , Bachelot A. , Bidet M. , Dulon J. , Thibaud E. , Polak M. , Touraine P.

Context: Early premature ovarian failure (ePOF) defined by cessation of ovarian function before age 18 is a rare condition. The link between puberty progression and POF hasnÂ’t been explored in details.Aim of study: To describe pubertal development and clinical practices of women with ePOF in a referral center for RME within the first 2 years follow-up.Description method/design: A mixed retrospective and prospective study was p...

ea0029p1609 | Thyroid (non-cancer) | ICEECE2012

Dyrk1A (dual-specificity thyrosine (Y)-phosphorylation regulated kinase 1A) overexpression is linked to congenital hypothyroidism in Down syndrome

Kariyawasam D. , Martin-Pena M. , Rachdi L. , Carre A. , Houlier M. , Dupuy C. , Janel N. , Delabar J. , Polak M.

Introduction: Trisomy 21 or Down Syndrome (DS) patients have a predisposition for Congenital Hypothyroidism which can aggravate their mental status.Hypothesis: The presence of three copy of Dyrk1a gene, localized in chromosome 21 in Humans, is responsible for a thyroidal dysgenesis.Our aim is to understand the molecular mechanisms underlying this condition.Methods: The transgenic Dyrk1a (TgDyrk1a) mouse, our ...