Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp242 | Anterior and Posterior Pituitary | ECE2019

Copeptin levels in SIADH – a marker of malignant disease?

Winzeler Bettina , Steinmetz Michelle , Refardt Julie , Cesana-Nigro Nicole , Popovic Milica , Fenske Wiebke , Christ-Crain Mirjam

Context: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common condition in hospitalized patients. It is crucial to establish the cause of SIADH especially in order to exclude or detect an underlying malignancy. As SIADH can be caused by paraneoplastically produced arginine vasopressin (AVP), we hypothesized that its stable surrogate marker copeptin may be used as a diagnostic tool.Methods: We analyzed ...

ea0063p230 | Pituitary and Neuroendocrinology 1 | ECE2019

The role of interleukin-1 in the dynamics of exercise-induced copeptin

Popovic Milica , Timper Katharina , Seelig Eleonora , Nordmann Thierry , Erlanger Tobias , Donath Marc , Christ-Crain Mirjam

Background: The goal of this project was to identify non-osmotic stimuli of arginine vasopressin (AVP) release during exercise. Non-osmotic AVP release can lead to severe hyponatremia in otherwise healthy marathon runners.Interleukin-1 (IL-1) increases during exercise and was shown to induce AVP in animal models. We here therefore investigated whether copeptin (a surrogate marker for AVP) increases upon exercise in young and healthy males, and whether this increase is regulate...

ea0035p313 | Clinical case reports Thyroid/Others | ECE2014

Ectopic co-secretion of growth hormone and growth hormone-releasing hormone from a neuroendocrine lung tumor in a patient with MEN1 syndrome

Isailovic Tatjana , Todorovic Vera , Milicevic Ivana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Skender-Gazibara Milica , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

The co-secretion of GHRH and GH has been described previously in a patient with GHRH producing pituitary somatotroph adenoma. Here we present a patient with MEN1 and ectopic secretion of both GHRH and GH from a neuroendocrine lung tumor.A 52-year-old woman was diagnosed in 2009 with two lung tumors, 4 cm right upper lobe tumor, and 2 cm left lower lobe tumor. Owing to a mild coarsening of facial features, acromegaly was suspected. Endocrine studies showe...

ea0073oc4.1 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2021

Effect of IL-1 receptor antagonism on hyperandrogenemia in women with polycystic ovary syndrome

Popovic Milica , Schiffer Lina , Taylor Angela E. , Arlt Wiebke , Vogt Deborah , De Geyter Christian , Sartorius Gideon , Donath Marc Y. , Christ-Crain Mirjam

BackgroundPolycystic Ovary Syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. The main components are hyperandrogenemia and oligo-/amenorrhea. The pathophysiology of PCOS is not fully understood which is why no causal treatment options are available. A multitude of observational studies demonstrated elevated C-reactive protein (CRP) levels in patients with PCOS compared with weight-matched controls. CRP is a sensitive ...

ea0063oc13.1 | Anterior and Posterior pituitary 2 | ECE2019

Arginine-stimulated copeptin measurements - a new test for diabetes insipidus

Winzeler Bettina , Nigro-Cesana Nicole , Refardt Julie , Vogt Deborah R , Imber Cornelia , Morin Benedict , Popovic Milica , Steinmetz Michelle , Sailer Clara , Szinnai Gabor , Chifu Irina , Fassnacht Martin , Christ-Crain Mirjam

Background: The differential diagnosis of diabetes insipidus is challenging. The most reliable diagnostic approach is hypertonic saline-stimulated copeptin measurements. However, as this test is based on the induction of hypernatremia, it is associated with adverse effects and needs close sodium monitoring. We hypothesized that arginine-stimulated copeptin measurements provide an alternative, simple and safe diagnostic test for diabetes insipidus.Methods...