Endocrine Abstracts

Fibro-adipogenic progenitors (FAPs), a muscle-resident stem cell population, have recently emerged as important actors of muscle regeneration by interacting with myogenic progenitors (MPs) to promote the formation of new muscle fibers. However, in pathological condition, as muscle dystrophies, this coordinated response is lost and then an accumulation of FAPs is observed. In particular, in a mouse model of Duchenne muscle dystrophy (mdx), the accumulation of a specific subpopu...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...

Background: Recent reports have suggested a link between the thyroid hormone (TH) signalling pathway and liver disease, including hepatocellular carcinoma (HCC). Deiodinases are enzymes responsible for the peripheral metabolism of TH. Although the expression of deiodinases type 1 (D1) and 3 (D3) has been shown to change during induced liver injury, their role in hepatocarcinogenesis is still poorly understood.Aims: To evaluate the role of deiodinases and...

Objective: decreased survival and higher cardiovascular risk have been reported in a UK cohort of RTHβ patients, but there is no evidence from other countries.Methods: retrospective study of an Italian cohort of RTHβ patients, carrying heterozygous pathogenic variants in the THRB gene and diagnosed in the period between 1984 and 2023. We collected records at diagnosis of 284 cases, whereas longitudinal data were available in 249 RTH&#9...