Searchable abstracts of presentations at key conferences in endocrinology

ea0032p726 | Obesity | ECE2013

The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet

Sieira Sonia Perez , Martinez Gloria , Porteiro Begona , Lopez Miguel , Vidal Anxo , Nogueiras Ruben , Dieguez Carlos

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

ea0032p753 | Obesity | ECE2013

Chronic central administration of amylin decreases fat mass but does not modify body weight

Touceda David Gonzalez , Pico Amparo Romero , Piedra Monica Imbernon , Couto Begona Porteiro , Tarrio Daniel Beiroa , Lopez Miguel , Nogueiras Ruben , Dieguez Carlos

Aims (objectives): Energy intake and expenditure are regulated by different signals. One of the molecules implicated is islet amyloid polypeptide (IAPP or amylin), one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a peptide that inhibits insulin and glucagon secretion, and can also act through the brain decreasing food intake and inhibiting gastric emptying. In this study, we investigated the potential effects of the chronic cent...

ea0056gp156 | Obesity | ECE2018

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

Rellan Maria Jesus Gonzalez , Couto Begona Porteiro , Fondevila Marcos Fernandez , Buque Xabier , Fernandez Uxia , Mora Alfonso , Beiroa Daniel , Lopez Miguel , Sabioc Guadalupe , Dieguez Carlos , Aspichueta Patricia , Nogueiras Ruben

Introduction: p53 is a transcription factor involved in many biological functions such as stress, ageing, and metabolism. Although there is a large body of evidence showing that p53 promotes fatty acid catabolism while it inhibits anabolism through the regulation of gene expression, the possible contribution of p53 to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains to be elucidated. Also, the anthracycline doxorubicin is an important chemotherapeutic agent...

ea0032p681 | Neuroendocrinology | ECE2013

Hypothalamic melanin-concentrating hormone influences liver and adipose lipid metabolism

Imbernon Monica , Beiroa Daniel , Vazquez Maria J , Morgan Donald A , Veyrat-Durebex Christelle , Porteiro Begona , Diaz-Arteaga Adenis , Senra Ana , Al-Massadi Omar , Velasquez Douglas A , Gallego Rosalia , Seoane Luisa M , Lopez Miguel , Davis Roger J , Sabio Guadalupe , Rohner-Jeanrenaud Francoise , Rahmouni Kamal , Dieguez Carlos , Nogueiras Ruben

Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...