Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep996 | Pituitary - Clinical | ECE2017

Sheehan syndrome presenting 21 years later as severe heart failure

Ferreira Ana Goncalves , Alegria Sofia , Cordeiro Maria Carlos , Portugal Jorge

Introduction: Sheehan syndrome (SS) is caused by postpartum necrosis of the pituitary gland, associated with significant haemorrhage during or after delivery. It is rare in developed countries, but still frequent in underdeveloped ones. We present a rare presentation of this syndrome.Clinical case: A 48 years old black woman presented at the emergency department for long term fatigue and dyspnea that worsened a few days before. Her physical examination r...

ea0070aep843 | Reproductive and Developmental Endocrinology | ECE2020

Hyperandrogenism in a postmenopausal woman secondary to an androgen secreting steroid cell tumor of the ovary

Bastos Filipa , Franco Sara , Ferreira Ana , Manita Isabel , Portugal Jorge

Introduction: Androgen secreting neoplasms of the ovary are rare and usually show autonomous secretion. Steroid cell tumors of the ovary represent less than 0.1% of all ovarian tumors and are a subgroup of sex cord-stromal tumors. In most cases, patients present with androgenic clinical features.Case report: A 58-year-old woman complained of rapid onset of androgenic alopecia, excessive hirsutism and clitoromegaly. Endocrine assessment showed high levels...

ea0055wa13 | Workshop A: Disorders of the hypothalamus and pituitary (I) | SFEEU2018

Cushing’s disease relapse associated with central diabetes insipidus

Ferreira Ana , Silva Tiago , Bastos Filipa , Manita Isabel , Cordeiro Maria Carlos , Portugal Jorge

Introduction: Central diabetes insipidus (DI) is a frequent complication of transfenoidal surgery for Cushing’s disease (CD). It can be transient or, more infrequently, permanent. The most common mechanism results from surgical neurohypophyseal damage rather than local mass effect from the pituitary adenoma.Case report: A 40 years old woman was referred to our Endocrinology outpatient clinic at the beginning of 2015 for new onset hypertension, signi...

ea0063p1076 | Pituitary and Neuroendocrinology 3 | ECE2019

Prolactinoma – is there a relationship between T2W signal intensity in MRI and response to treatment with dopamine agonists?

Ferreira Ana , Oliveira Guilherme , Bastos Filipa , Carlos Cordeiro Maria , Duarte Julia , Portugal Jorge

Introduction: Prolactinomas are mostly benign tumours usually managed with pharmacological treatment. Some, however, seem to be resistant to dopamine agonists (DA) for unclear reasons. The relationship between T2W signal intensity (T2WSI) and response to treatment with somatostatin analogs is well described in acromegaly patients. Some evidence suggests that prolactinoma’s T2W hypointensity might be related to higher baseline prolactin levels and more resistance to DA.</p...

ea0063p1081 | Pituitary and Neuroendocrinology 3 | ECE2019

ACTH-positive diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH)

Ferreira Ana , Bastos Filipa , Pedro Paula , Lopes Miguel , Carlos Cordeiro Maria , Portugal Jorge

Introduction: DIPNECH is a preinvasive condition in which there is an idiopathic generalised proliferation of pulmonary neuroendocrine cells that can form tumourlets. There are very few cases described of ACTH secretion by these cells causing Cushing’s syndrome, some of them cyclic.Case report: A 41 year-old woman was sent to our Endocrinology outpatient clinic for menstrual disturbance, acne and excessive sweating. She had a recent diagnosis of DIP...

ea0049ep226 | Bone &amp; Osteoporosis | ECE2017

Cinacalcet for control of primary hyperparathyroidism: a single centre experience

da Silva Tiago Nunes , Ferreira Ana Goncalves , Cordeiro Maria Carlos , Matos Ana Catarina , Portugal Jorge

Although primary hyperparathyroidism (PHPT) is usually cured by surgery, some individuals are unable to undergo parathyroidectomy and are refractory to standard calcium lowering medical therapy. In such cases, targeted therapy with cinacalcet may be useful.The aim of this study was to access the short-term efficacy of cinacalcet in lowering calcium (Ca2+) levels in patients with PHPT unable to undergo parathyroidectomy and refractory to standa...

ea0020p533 | Paediatric Endocrinology | ECE2009

Prevalence of autoimmune thyroiditis in children with diabetes mellitus

Veloza Andreia , Coelho Catarina , Manita Isabel , Cordeiro Maria , Passos Dolores , Raimundo Luisa , Portugal Jorge

Introduction: Type 1 diabetes mellitus (DM1) is frequently associated with other autoimmune diseases. Among children and adolescents, thyroid disease is the most common autoimmune endocrinopathy. The possibility of occult thyroid disease should be considered at diagnosis and when a patient is assessed at the annual review.Objective: The aim of our study was to determine the prevalence of autoimmune thyroiditis among children and adolescents with type 1 d...

ea0014p424 | (1) | ECE2007

Juvenile osteoporosis in untreated GH-deficient patient – is treatment with GH replacement indicated? A clinical case report

Coelho Catarina , Saraiva Catarina , Manita Isabel , Velosa Andreia , Passos Dolores , Carlos Maria , Raimundo Luisa , Portugal Jorge

Treatment for osteoporosis in children/adolescents is extremely important not only to improve bone quality but also because, if left untreated, could lead to severe and precocious loss of bone mass. Studies in growth hormone (GH) deficient adults, in turn, have shown that treatment with GH produce bone mass gain and improve the occurrence of both bone formation and reabsorption.The authors present the following case report of a 16 year old Caucasian fema...

ea0063p990 | Diabetes, Obesity and Metabolism 3 | ECE2019

What is the factor that most influences perinatal outcomes in pregnant women with Gestational Diabetes Mellitus: Country of origin or previous Gestational Diabetes?

Ferrinho Catia , Matos Ana Catarina , Cordeiro Maria Carlos , Bastos Filipa , Ferreira Rute , Duarte Joao Sequeira , Oliveira Manuela , Portugal Jorge

Introduction: Gestational Diabetes Mellitus (GDM) is one of the pregnancy diseases with the highest rate of complications, influenced by several factors. Its prevalence has increased, with a prevalence of 7.2% in Portugal.Objective: Characterize pregnant women with GDM and evaluate the perinatal outcomes according to the country of origin and previous GDM.Material and methods: Cross-sectional and retrospective study. We collected c...

ea0049ep486 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Insulin autoimmune syndrome: the relationship between insulin, c-peptide and glucose in active and recovering disease states

da Silva Tiago Nunes , Ferreira Ana Goncalves , Manita Isabel , Matos Ana Catarina , Carvalho Isabel , Font Paula , Prazeres Susana , Portugal Jorge

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...