ea0022p168 | Cardiovascular endocrinology and lipid metabolism | ECE2010
Posa Aniko
, Szablics Peter
, Vari Beata
, Szalai Zita
, Kiss Gyongyi Karcsune
, Varga Csaba
, Laszlo Ferenc
In the reproductive age, it is well-known that males are more sensitive to cardiovascular ischemic disease than females. In our study, we investigated the role of heme-oxigenase synthase (HO), which produce endogenous vascular protective carbon monoxide, in the development of sexual dimorphism in rats. We found that HO synthase enzyme activity, and the expression its HO-1 and HO-2 isoenzyme were increased in female rat aorta and left heart ventricle compared to males. Moreover...