Searchable abstracts of presentations at key conferences in endocrinology

ea0028s6.3 | Inhibiting steroid enzymes to treat common diseases | SFEBES2012

Dual aromatase and steroid sulphatase inhibition in breast cancer

Foster Paul , Potter Barry , Purohit Atul

The production of oestradiol (E2) is paramount for the growth of oestrogen receptor α positive breast cancer. Various strategies have been used, including the use of enzyme inhibitors against either aromatase (AROM) or steroid sulphatase (STS), in an attempt to ablate E2 levels. Both these enzymes play a critical role in the formation of oestrogenic steroids (see figure 1) and their inhibitors are now showing success in the clinic. The studies presented here demonstrate t...