ea0025p250 | Pituitary | SFEBES2011
Prescott Helen
, Munir Alia
, Canton Irene
, Battaglia Giuseppe
, Newell-Price John
Background: Previously, we have demonstrated highly potent knockdown of POMC mRNA and significant reduction in secreted ACTH using siRNA, both in vitro and in vivo. Highly efficient delivery of siRNA to a target tissue is of critical importance for any therapeutic approach. Here we assess the suitability of a pH-sensitive polymer, PMPC-PDPA polymersomes encapsulating siRNA, as a novel delivery system as these have potential for tissue-directed delivery by ...