Searchable abstracts of presentations at key conferences in endocrinology

ea0022p702 | Obesity | ECE2010

Acylated, unacylated ghrelin and obestatin regulation during oral glucose tolerance test in obese prepubertal and pubertal children

Prodam Flavia , Bellone Simonetta , Petri Antonella , Trovato Letizia , Genoni Giulia , Dondi Elena , Demarchi Irene , Bona Gianni

Physiological role of acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin is poorly understood especially in childhood. To understand their biological implications in obesity and metabolic syndrome (MS), we measured AG, UAG, obestatin, at fasting and every 60′ during oral glucose tolerance test (OGTT) in 60 prepubertal (PP–OB; 32) and pubertal (P-OB; 28) children. Paediatric IDF 2007 criteria was used to identifying MS. In PP-OB group, 20 (62.5%) children ...

ea0014p575 | (1) | ECE2007

The GH releasing activity of ghrelin is insensitive to the negative growth hormone (GH) autofeedback in humans

Riganti Fabrizio , Prodam Flavia , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Ghigo Ezio , Broglio Fabio

Growth hormone (GH) secretion is regulated by a complex interplay between GH-releasing hormone (GHRH), somatostatin and several other central and peripheral modulatory signals. Ghrelin has been hypothesized as physiological amplifier of GH pulsatility and acts via mechanisms, at least partially, independent of GHRH and somatostatin. The GH response to GHRH is strongly inhibited by previous administration of recombinant human GH (rhGH), likely as a consequence of a somatostatin...

ea0073aep201 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

ea0081ep569 | Endocrine-Related Cancer | ECE2022

Novel pathogenetic mutation of MEN1 gene causing hyperparathyroidism, pancreatic glucagonoma, adrenal adenoma, and collagenomas

Pitino Rosa , Vimercati Davide , Pizzolitto Francesca , Mollero Edoardo Luigi Maria , Daffara Tommaso , Ferrero Alice , Boldorini Renzo , Caputo Marina , Prodam Flavia

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

ea0035p27 | Adrenal cortex | ECE2014

A three generation family with low cortisol, CBG deficiency, chronic fatigue and pain, lipomatosis and behavioral alterations

Moia Stefania , Walker Gillian Elisabeth , Roccio Marta , Ricotti Roberta , Giglione Enza , Bellone Simonetta , Fanelli Flaminia , Bona Gianni , Prodam Flavia

Introduction: CBG is the main transport protein for glucocorticoids in blood. CBG gene is a member of the serine protease inhibitor family, located at chromosome 14q32. Inherited CBG deficiency (MIM 611489) is a rarely recessive disorder, and the phenotype associated includes low cortisol levels, presence of normal ACTH levels, hypotension and fatigue, although the exact pathophysiological mechanisms involved remain uncertain. We identified a family with a complex phe...

ea0035p145 | Calcium and Vitamin D metabolism | ECE2014

The association between vitamin D deficiency and metabolic parameters in pediatric obesity is influenced by what surrogate index of sunlight exposure is used

Prodam Flavia , Zanetta Sara , Bellone Simonetta , Ricotti Roberta , Giglione Enza , Marolda Agostina , Petri Antonella , Zavattaro Marco , Aimaretti Gianluca , Bona Gianni

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

ea0032p467 | Diabetes | ECE2013

Efficacy and safety of 1 year treatment with Liraglutide in subjects with type 2 diabetes

Prodam Flavia , Zavattaro Marco , Ponziani Chantal , Pagano Loredana , Caputo Marina , Allochis Gabriele , Teresa Sama Maria , Busti Arianna , Aimaretti Gianluca

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

ea0032p473 | Diabetes | ECE2013

Cardiovascular effects of treatment with Liraglutide in a population with type 2 diabetes

Zavattaro Marco , Prodam Flavia , Grazia Mauri Maria , Pagano Loredana , Caputo Marina , Belcastro Sara , Allochis Gabriele , Aimaretti Gianluca

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

ea0032p851 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A precocious GH peak at GHRH plus arginine test in GH sufficient short children is predictive of a lower growth velocity

Prodam Flavia , Castagno Matteo , Bellone Simonetta , Genoni Giulia , Giglione Enza , Marolda Agostina , Petri Antonella , Aimaretti Gianluca , Bona Gianni

Introduction: Generously supported by IPSEN)-->In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.Subjects and methods: Children who performed a GHRH plus ARG ...

ea0026p381 | Thyroid (non cancer) | ECE2011

ESE Young Investigator Award

Moia Stefania , Prodam Flavia , Monzani Alice , Bellone Simonetta , Riccomagno Stefania , Walker Gillian , Trovato Letizia , Roccio Marta , Agretti Patrizia , Bona Gianni

TSH receptor (TSHR) is a G-protein-coupled seven-transmembrane domain receptor located in the basolateral membrane of thyroid follicular cells. The activated receptor couples to two major signal transductions pathways: the Gs/adenylate cyclase and the Gq/11/phospholipase C signalling. Many loss of function mutations have been identified in this gene leading to a wide spectrum of thyroid abnormalities, ranging from hyperthyrotropinemia and TSH resistance to severe hypothyroidis...