Searchable abstracts of presentations at key conferences in endocrinology

ea0081p659 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of copeptin levels during glucagon stimulation test in children with suspected growth hormone deficiency

Ferrante Emanuele , Giacchetti Federico , Indirli Rita , Profka Eriselda , Rodari Giulia , Giavoli Claudia , Mantovani Giovanna , Arosio Maura

Introduction: Glucagon stimulation test is one of the recommended growth hormone provocation tests for diagnosing growth hormone deficiency in children. In adult patients, recent data showed that glucagon administration is able to stimulate the release of copeptin, the stable C-terminal glycopeptide of the AVP prohormone whose evaluation during hypertonic saline infusion represents the gold standard for the differential diagnosis of polyuria/polydipsia. However, similar data o...

ea0090rc4.6 | Rapid Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Bone and sexual health in adult women with complete androgen insensivity syndrome: A single centre experience

Profka Eriselda , Rodari Giulia , Giacchetti Federico , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: Low bone mineral density (BMD) and reduced sexual satisfaction have been reported in complete androgen insensitivity syndrome (CAIS). Nevertheless, conclusive data on the prevalence and on the optimal management of these conditions are still lacking.Aims: To assess bone and sexual health in adult women with CAIS with and without gonadectomy.Methods: Single-centre, prospective study of 27 adult CAIS (age 35.2±8.7 ye...

ea0090p453 | Reproductive and Developmental Endocrinology | ECE2023

In between isolated premature thelarche and central precocious puberty: when DHEAS makes the difference

Rodari Giulia , Collini Valentina , Giacchetti Federico , Profka Eriselda , Arosio Maura , Mantovani Giovanna , Giavoli Claudia

Background: Precocious puberty (PP) in girls is most frequently an idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP, being thelarche the typical first sign. It is well established that increased dehydroepiandrosterone sulphate (DHEAS) levels are associated with premature adrenarche and may characterize PP too. However, its relationship with signs of hypothalamic-pituitary-gonadal (HPG) axis activation and oestrogen exposure is still to be elucidated.<p class="...

ea0070aep571 | Pituitary and Neuroendocrinology | ECE2020

Deletion of chromosome 1q24-1q32 and combined pituitary hormone deficiency type 4: Insight into the challenges of genotype-phenotype correlation

Giavoli Claudia , Ubertini Graziamaria , Giacchetti Federico , Rodari Giulia , Profka Eriselda , Cianfarani Stefano , Arosio Maura , Cappa Marco

Background: Interstitial deletions of the long arm of chromosome 1 are rare and classified as proximal or intermediate, the intermediate spanning bands 1q24–1q32. This region contains several genes, including LHX4, a LIM-homeodomain transcription factor essential in the early steps of pituitary ontogenesis. Indeed, mutations in the LHX4 gene are related to combined pituitary hormone deficiency type 4 (CPHD4, OMIM 602146).Aim: outline the impact of ...

ea0070aep572 | Pituitary and Neuroendocrinology | ECE2020

Baseline IGF-I values influence the effect of rhGH therapy on fat mass: Short, medium and long term study on adults with GH deficiency

Profka Eriselda , Rodari Giulia , Giacchetti Federico , Draghi Alessandro , Arosio Maura , Giavoli Claudia

Background: One of the main effects of growth hormone therapy (rhGH) in the adult GH deficient patient (AGHD) is to positively modify body composition, with a reduction in fat mass (BF) and an increase in total lean mass (LM). However, the response to replacement therapy is highly variable and, contrary to what described in children, the potential predictive factors are not yet known.Aim of the study: To assess the impact of basal IGF-I levels on variati...

ea0070aep765 | Pituitary and Neuroendocrinology | ECE2020

Controversies in the spectrum of GH-IGF-I axis disorders requiring replacement therapy

Rodari Giulia , Cavenaghi Ivan , Profka Eriselda , Giacchetti Federico , Arosio Maura , Giavoli Claudia

Background: Growth hormone deficiency (GHD) is the most frequent endocrinological disorder inchildren with short stature, but there are significant controversies in the diagnosis due to lack of reliablediagnostic criteria. Moreover, at final height (FH) attainment, many subjects diagnosed withisolated GHD re-test normal. It is not clear whether this represents a form of transient GHD or a false positive diagnosis during childhood.Aim: To evaluate differe...

ea0081ep869 | Reproductive and Developmental Endocrinology | ECE2022

Procoagulant imbalance in male hypogonadism and effect of short-term testosterone replacement therapy

Indirli Rita , Clerici Marigrazia , Lanzi Valeria , Profka Eriselda , Cangiano Biagio , Bonomi Marco , Arosio Maura , Mantovani Giovanna , Tripodi Armando , Ferrante Emanuele

Introduction: The effects of testosterone on coagulation have not yet been clarified. In particular, it is still controversial whether male hypogonadism, or testosterone replacement therapy (TRT), may slightly increase the risk of venous thromboembolism, in particular during the first months of therapy. This study aimed to assess the hemostatic balance in hypogonadal men before and after short-term TRT, compared to healthy controls.Methods: Thrombin gene...

ea0081rc12.7 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Pubertal induction in girls with hypogonadism: insight into estrogen replacement therapy outcomes and optimization of progesterone introduction

Rodari Giulia , Federici Silvia , Cattoni Alessandro , Todisco Tommaso , Ubertini Graziamaria , Giacchetti Federico , Profka Eriselda , Dall'Antonia Alberta , Cangiano Biagio , Arosio Maura , Bonomi Marco , Cappa Marco , Giavoli Claudia

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at mimicking physiological puberty. To date, the best induction regimen is still to be established.Aims: By setting up a multicentre clinical registry, we analysed longitudinal data on pubertal induction in girls with hypogonadotropic hypogonadism or premature ovarian insufficiency (congenital, acquired, isolated or associated with multiple pituitary...

ea0041gp156 | Pituitary - Clinical | ECE2016

Natural history of a large cohort of pituitary incidentalomas in Italy

Tresoldi Alberto Stefano , Toini Alessandra , Profka Eriselda , Locatelli Marco , Lasio Giovanni Battista , Morenghi Emanuela , Spada Anna , Mantovani Giovanna , Lania Andrea Gerardo

In this observational, retrospective, multicenter study, we analyzed data from 300 patients with pituitary incidentaloma followed in two Italian Hospital Center. We observed a predominance of female patients (65%), with an a mean age at diagnosis of 49 years (higher in men than women, 57 vs 45 years old). The main reason to perform imaging were neurological symptoms not related to the presence of adenomas (56%). Most cases were microadenomas (56%), and macroadenomas were more ...

ea0035p898 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Recurrence of hyperprolactinemia after withdrawal of cabergoline in prolactinomas

Sala Elisa , Bellaviti Paola , Ferrante Emanuele , Malchiodi Elena , Verrua Elisa , Giavoli Claudia , Profka Eriselda , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Introduction: The optimal treatment duration for prolactinomas to minimize reccurences is not clear. 2011 Endocrine Society Guidelines suggested that cabergoline withdrawal may be safely undertaken after 2 years in patients achieving normoprolactinemia and tumor volume reduction.Materials and methods: We analyzed 74 patients (mean age=46.9±14.4, M/F=19/56, macro/micro=18/56) bearing a prolactinoma. Patients were divided in 3 groups: Group A (23) tre...