Searchable abstracts of presentations at key conferences in endocrinology

ea0003p248 | Steroids | BES2002

The relationship between smoking, statin therapy and testosterone in men with coronary artery disease

Morris P , Pugh P , Hall J , Channer K , Jones T

BACKGROUND: We have previously shown that men with coronary artery disease (CAD) have lower serum bioavailable testosterone levels than men with normal coronary arteries and this may have detrimental effects in coronary disease. It has been suggested that low androgen levels in men with CAD could be accounted for by the high prevalence of statin therapy and other factors such as smoking. We investigated the effects of statin therapy and smoking on testosterone in men with CAD....

ea0003p249 | Steroids | BES2002

Androgens and diabetes mellitus in men with coronary artery disease

Morris P , Pugh P , Roberts S , Channer K , Jones T

BACKGROUND: Previous work has demonstrated a relationship between impaired carbohydrate metabolism and low serum levels of androgens in men. Men with diabetes have lower testosterone levels, and administration of physiological doses of testosterone improves glucose tolerance in these men. Men with coronary artery disease (CAD) have lower androgen levels than men with normal coronary arteries. We studied the relationship between testosterone, glucose, hypertension and DM in a p...

ea0006p26 | Diabetes, metabolism and cardiovascular | SFE2003

The relationship between serum levels of testosterone and inflammatory cytokines in men wih coronary artery disease

Nettleship J , Jones R , Pugh P , Channer K , Jones T

Evidence supports a protective role for testosterone in men with coronary artery disease (CAD) and in the regulation of cytokine function. This study examined the relationship between serum levels of inflammatory cytokines and testosterone in men with CAD. Serum was collected from 69 men (59+1 years) having >75% occlusion of 1 (n=20), 2 (n=18) or 3 (n=31) coronary arteries. Levels of total testosterone (TT), bioavailable testosterone (BT), tumour necrosis factor-alpha (TNFa...

ea0005oc13 | Cardiovascular Endocrinology | BES2003

Assessment of the vasodilatory action of testosterone in isolated human pulmonary and mesenteric arteries and veins

Rowell K , Jones R , Pugh P , Channer K , Jones T

Testosterone therapy has been shown to benefit men with heart failure or coronary artery disease, an activity proposed to be mediated via its vasodilatory efficacy. Testosterone has been demonstrated to dilate human coronary arteries, but it is unknown whether testosterone has a similar action in human pulmonary or systemic vessels.Male patients were recruited from cardiothoracic (n = 14, age = 68 plus/minus 9) or gastrointestinal (n = 8, age = 70 plus/minus 3) operating l...

ea0005p83 | Diabetes, Metabolism and Cardiovascular | BES2003

Testosterone is a dilator of resistance arteries in men with congestive heart failure

Malkin C , Pugh P , Jones R , Jones T , Channer K

BackgroundHeart failure is a syndrome of vaso-constriction and hormone abnormalities. There is an excess of catabolic and vasoconstrictor hormones and a relative deficiency of anabolic hormones. Vaso-dilating drugs improve symptoms in heart failure and inhibition of some catabolic / vasoconstrictor hormones improves prognosis. We aimed to study the direct vascular effects of testosterone resistance arteries from men with heart failure.Methods6 resistance arteries w...

ea0005p100 | Diabetes, Metabolism and Cardiovascular | BES2003

Treatment of coronary disease and effects on endogenous testosterone levels

Malkin C , Pugh P , Jones T , Channer K

Background. Males with coronary disease have lower levels of endogenous testosterone than unaffected males. It is not known if low testosterone is a cause, effect or an epi-phenomenon of ischaemic heart disease.We hypothesised that androgen deficient men treated surgically with complete resolution of their symptoms would have a higher subsequent testosterone than men with persistent angina.Methods. Subjects were recruited after angiography. All subjects were biochemically ...

ea0004p37 | Diabetes, metabolism and cardiovascular | SFE2002

Haemodynamic effects of acute buccal administration of testosterone in men with heart failure

Pugh P , Malkin C , Jones R , Channer K , Jones T

Background: Testosterone treatment has been shown to increase exercise capacity in men with chronic heart failure but the mechanism of benefit is unclear. The purpose of this study was to examine the acute haemodyamic effects of testosterone in men with heart failure.Methods: Twelve men with stable heart failure (age 62.8 (8.8)years; ejection fraction 30.9 (6.3)% (NR>60%)) were enrolled in a double-blind, placebo-controlled cross-over study. Cardiac o...

ea0003p251 | Steroids | BES2002

Testosterone therapy improves depressive symptoms in men with chronic heart failure

Pugh P , Jones R , Hall J , Channer K , Jones T

Objectives: Testosterone deficiency has been associated with depressive symptoms, which may be improved by replacement therapy. Patients with chronic heart failure have a high prevalence of depression, which is associated with early mortality in these patients. Men with heart failure may also have low plasma levels of testosterone, which could contribute to depressed mood. In a clinical study investigating whether testosterone treatment benefits men with heart failure, patient...

ea0002oc8 | Vascular and Metabolic | SFE2001

Vascular reactivity and response to testosterone is unaltered in testicular feminised mice

Pugh P , Jones R , English K , Channer K , Jones T

Background: Current evidence suggests that testosterone acts as a vasodilator in several vascular beds. This may have implications for men who are androgen deficient, in whom vascular reactivity may be impaired. We have studied vascular responses in vitro in femoral arteries from testicular feminised mice (Tfm), which lack a functional androgen receptor and are consequently androgen resistant and have reduced circulating levels of testosterone. Methods: Femoral arteries from m...

ea0009oc9 | Oral Communication 1: Diabetes and metabolism | BES2005

Testosterone improves funtional capacity and symptoms in men with chronic heart failure: a double blind placebo controlled trial

Malkin C , Pugh P , Jones R , van Beek E , West J , Channer K , Jones T

Chronic heart failure (CHF) is associated with maladaptive and prolonged neurohormonal and pro-inflammatory cytokine activation causing a metabolic shift favouring catabolism, vasodilator incapacity, and loss of skeletal muscle bulk and function. In men, androgens are important determinants of anabolic function and physical strength and also possess anti-inflammatory and vasodilatory properties. We conducted a randomised, double blind, placebo controlled trial of testosterone ...