ea0049oc6.5 | Diabetes therapy and complications | ECE2017
Perez-Fuentes Ricardo
, Pulido Patricia
, Cazares Joshua
, Inostroza-Nieves Yaritza
, Torres-Rasgado Enrique
, Nishiyama Akira
, Rivera Alicia
, Ortiz Rudy
, Romero Jose
Insulin resistance and type II diabetes (T2D) are associated with activation of the Renin-Angiotensin-Aldosterone-System (RAAS) in part via regulation of its principal effector molecule, Angiotensin II (AngII). Endothelial cell activation leads to, among other factors, increased extracellular protein disulfide isomerase (PDI), a multifunctional protein that is critical to thrombus formation and regulation of reactive oxygen species. However, the effects of RAAS on PDI are unkn...