Endocrine Abstracts

Introduction: Surgical management of clinically N0 (cN0) patients with thyroid carcinomas remains debatable due to various reported frequencies of lymph node (LN) metastases. The aim of this paper was to present usefulness of sentinel lymph node biopsy (SLNB) of jugulo-carotid regions after methylene blue dye (MBD) mapping in intraoperative selection of cN0 patients with papillary and medullary thyroid carcinomas for one-time lateral neck dissection (LND).<p class="abstext...

Introduction: Serum calcitonin level (sCT) is a precise marker for medullary thyroid carcinoma (MTC). However, lymph node (LN) metastases can be found in lower sCT, as well, and preoperative ultrasound may provide false negative findings on regional LNs. The aim was to present original technique of sentinel lymph node (SLN) biopsy of jugulo-carotid regions, after methylene blue dye mapping procedure, and its usefulness for selection of clinically N0 patients with MTC for modif...

Introduction: Serum calcitonin levels (sCT) in medullary thyroid carcinoma (MTC) correlate with the tumour size and disease progression. Lymph node (LN) metastases can be verified even in sCT lower than 100 pg/ml. The extent of LN dissection has not yet been standardised. The aim of this pilot study was to show our experience with sentinel lymph node (SLN) biopsy of jugulo-carotid chain (JCC) in selection of patients with MTC for modified radical neck dissection (MRND).<p ...

Background: Well-differentiated thyroid carcinoma in children is rare but it shows aggressive behaviour. Gross lymph node metastases and distant metastases are common on first clinical presentation.Patients and methods: During 33 years (1981–2014) at the Institute of Oncology and Radiology of Serbia 24 children were operated due to papillary thyroid carcinoma. Mean age was 12.6 (range 7–16) years. At the time of diagnosis 12.5% patients had lun...

Introduction: The aim of this study was to determine frequency of lymphonodal metastases in jugulo-carotid chain (JCC) and central neck compartment in incidental thyroid microcarcinomas (ITMC), as well as to examine whether sentinel lymph node (SLN) biopsy of JCC is an accurate technique to select patients with true positive, but clinically and ultrasonically negative lymph nodes, for modified radical neck dissection (MRND).Materials and methods: Out of ...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy (80%), while primary thyroid lymphomas (PTL) occur in only 0.6–5% of cases. A significant number of PTCs, as well as PTLs, arise in the setting of Hashimoto’s thyroiditis (HT), however the simultaneous occurrence of these two malignancies is extremely rare.Case report: We present a 34-year-old female patient with thyroid MALT lymphoma and coexisting papillary ...

Introduction: The aim of this study was to determine whether sentinel lymph node (SLN) biopsy of jugulo-carotid chain (JCC) in thyroid microcarcinomas (TMC) is an accurate technique to select patients with true positive, but clinically and ultrasonically N0 LNs, for modified radical neck dissection (MRND).Materials and methods: In total 199 patients with TMC underwent total thyroidectomy, central neck dissection and SLN mapping with 0.2 ml of 1% methylen...

Background: Papillary thyroid carcinoma in children and adolescents is rare but it shows aggressive behavior. Gross lymph node metastases and distant metastases are common on first clinical presentation.Patients and methods: Forty-eight children and adolescents were operated due to PTC. Mean age was 16.6 years (range 7–21). At the time of diagnosis 13% had lung metastases. Total thyroidectomy or completion of thyroidectomy was performed in all cases...

Introduction: Surgical management of clinically N0 (cN0) patients with thyroid carcinomas remains debatable due to various reported frequencies of lymph node (LN) metastases. Preoperative ultrasound identifies only half of LN metastases found at surgery. The aim of this report was to present our experience with sentinel lymph node biopsy (SLNB) of jugulo-carotid regions, after methylene blue dye (MBD) mapping and frozen section analysis (FSA), in detection of LN metastases in ...

Introduction: The incidence of occult lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) reaches 80%, still their surgical management in clinically node negative (cN0) patients remains controversial and ranges from ‘wait and see’ principle to prophylactic dissections of both central and lateral neck compartments. This encouraged some authors to apply the concept of sentinel lymph node biopsy (SLNb) in PTC. Our aim to investigate if SLNb using methylene ...