ea0098b25 | Basic Science | NANETS2023
Eagal Erika
, Lou Emil
, Gandhi Nishant
, Elliott Andrew
, Sukrithan Vineeth
, Vijayvergia Namrata
, Puri Sonam
, Chauhan Aman
, Hadfield Matthew
, Florou Vaia
, Affolter Kajsa
, Vanderwalde Ari
, Soares Heloisa P.
Background: Significant advances have been made in the treatment of gastrointestinal (GI-) and pancreatic (P-) NENs. However, the use of immunotherapy is still limited, with most tumors considered immune cold. The cGAS-STING signaling pathway has emerged as a critical mediator of inflammation and immune-mediated responses, with pathway agonists under development for enhancing immunotherapy. In this study, we evaluated associations between cGAS-STING pathway activit...