Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.08.08 | Reproduction: Male and endocrine disruptors | ECE2015

Evidence of stimulation of pubertal development and suppression of growth rate in boys smoking marijuana in cigarettes

Jabeen Shagufta , Raja Ghazala Kaukab , Akram Maleeha , Ahmad Afzal , Qayyum Mazhar , Rizvi Shakeel Raza

Evidence indicates that normal pattern of progression of puberty is altered under certain conditions of stress, whereas growth rate is affected by sustained higher concentrations of cortisol, a marker of stress reactivity. Available data show that early teens commonly resort to use of drugs. The use of drugs may evoke stress responses, which may alter pubertal development and affect growth rate. Body weight (BW), height, BMI and plasma concentrations of LH, testosterone (T), G...

ea0037ep172 | Reproduction, endocrine disruptors and signalling | ECE2015

Reduction of growth and lesser utilisation of energy reserves in heroin addicted boys during pubertal development

Saqlain Muhammad , Raja Ghazala Kaukab , Akram Maleeha , Minallah Samar , Ahmad Afzaal , Qayyum Mazhar , Rizvi Shakeel Raza

The secretion of leptin, an indicator of energy reserves, declines as energy stores are consumed in growth and development at puberty. The pubertal growth and development are often altered under different kinds of stresses. Usually, stress stimulates the release of cortisol, which is a labelled marker of stress. Early teens are inclined to drug abuse that may put their bodies under stress and may induce excessive secretion of cortisol. Since, sustained high levels of cortisol ...

ea0035p1031 | Thyroid (non-cancer) | ECE2014

An increase in the circulating concentrations of triiodothyronine appears to be a function of the peripheral conversion of tetraiodothyronine by deiodinases instead of increased stimulation by thyroid stimulating hormone at puberty in normal healthy boys

Rizvi SSR , Asif Hafsa , Saqib Sadia , Perveen Nadia , Shaheen Ghazala , Naseem AA , Tahir Faheem , Qayyum Mazhar

Thyroid stimulating hormone (TSH) causes synthesis of 90% of pro-hormone tetraiodothyronine (T4) and 10% of active triiodothyronine (T3) from thyroid gland. T3 regulates energy metabolism, thermogenesis, body temperature and normal brain development. T3 is produced from deiodination of T4 and circulating levels of T3 are regulated by deiodinases in response to body’s needs. The peripheral conversion of T<su...

ea0081p286 | Adrenal and Cardiovascular Endocrinology | ECE2022

A novel mutation in creb3l1 gene involved in vasopressin synthesis pathway in patients with hypertensive cardiovascular diseases

Rauf Sania , Arshad Abida , Foo Roger , Akram Maleeha , Naz Shumaila , Naseem Afzaal Ahmed , Qayyum Mazhar , Raza Rizvi Syed Shakeel

Arginine vasopressin (AVP) is a neurohormone, which regulates blood and extracellular fluid volume and hence blood pressure (BP). AVP has its chief action in kidneys where it reduces flow of urine, increases permeability of convoluted tubules of kidneys to water and its reabsorption. It binds to receptors on sweat glands and decreases water loss by perspiration from the skin. Also, AVP binds to peripheral arteriolar receptors, causing vasoconstriction and increase in BP. The s...

ea0081p287 | Adrenal and Cardiovascular Endocrinology | ECE2022

Whole exome sequencing of genes involved in dysfunctional renin-angiotensin-aldosterone system in hypertensive cardiovascular patients

Rauf Sania , Arshad Abida , Foo Roger , Akram Maleeha , Naz Shumaila , Ahmed Naseem Afzaal , Qayyum Mazhar , Raza Rizvi Syed Shakeel

The renin-angiotensin-aldosterone system (RAAS) is an endocrine system within the body that is essential for regulation of blood pressure (BP) and fluid balance. The system is mainly comprised of three hormones renin, angiotensin II (Ang II) and aldosterone. The RAAS pathway is initiated in the kidney with the proteolytic conversion of liver derived angiotensinogen to angiotensin I (Ang I) by renin secreted by juxtaglomerular apparatus of the nephron. Ang I is cleaved by angio...

ea0049ep1092 | Developmental endocrinology | ECE2017

Age and developmental stage dependent relationship between plasma concentrations of leptin, luteinizing hormone, follicle stimulating hormone, prolactin, testosterone and inhibin B in boys between the age of 1 and 20 years

Naseem Afzaal Ahmed , Qayyum Mazhar , Akram Maleeha , Iqbal Zubaria , Tahir Fahim , Afshan Kiran , Jahan Sarwat , Rizvi Syed Shakeel Raza

Leptin is regarded as an essential adipokine for controlling energy homeostasis, caloric intake reduction and increase of caloric expenditure by negative feedback mechanisms via receptors in the hypothalamus. Puberty is said to be triggered by leptin, which signals the hypothalamus that adequate fat reserves are available for initiation of energetically costly process of reproduction. Leptin activates gonadotropin releasing hormone (GnRH) system, which stimulates luteinizing h...

ea0049ep1225 | Paediatric endocrinology | ECE2017

Age and development stage dependent association between thyroid hormones and growth hormone and linear growth velocity in boys between the age of 1 and 20 years

Naseem Afzaal Ahmed , Qayyum Mazhar , Akram Maleeha , Iqbal Zubaria , Tahir Faheem , Jahan Sarwat , Afshan Kiran , Rizvi Syed Shakeel Raza

During the time of puberty, thyroid hormones (THs), thyroxin (T4) and triiodothyronine (T3), influence growth and developmental processes by working in association with growth hormone (GH), insulin like growth factor-I (IGF-1), glucocorticoids, insulin and gonadal steroids. THs have a direct effect on GH secretion, which stimulates IGF system. It has been suggested that THs control increase in bone length through synergy with GH. This investigation determ...

ea0037ep107 | Steroids, development and paediatric endocrinology | ECE2015

Paediatric hypothyroidism: effect of thyroxin replacement therapy on growth hormone secretion and linear growth velocity

Saqib Sadia , Kiani Amjad Rashid , Anwar Urooj , Akram Maleeha , Shahid Gulbin , Ishtiaq Osama , Ahmad Afzaal , Qayyum Mazhar , Rizvi Shakeel Raza

Thyroid gland secretes thyroid hormones, which play a critical role in growth, differentiation, reproduction and metabolism, whereas hypothyroidism in children is associated with short stature and normalisation of thyroid function with thyroxin replacement therapy increases linear growth velocity (LGV). In stimulating LGV, thyroxin may have its direct effects on bone cells or it may affect LGV through its effect on growth hormone (GH) secretion. The present study attempted to ...

ea0037ep768 | Pituitary: clinical | ECE2015

Exogenous administration of GH increases linear growth velocity at higher doses during pre- and early puberty in GH deficient short stature children

Anwar Urooj , Kiani Amjad Rashid , Saqib Sadia , Akram Maleeha , Shahid Gulbin , Ishtiaq Osama , Ahmad Afzaal , Qayyum Mazhar , Rizvi Shakeel Raza

In GH deficiency (GHD), which is a medical condition caused by problems in the pituitary gland, the body does not produce sufficient amount of GH, resulting in short stature in children. The treatment of GHD short children with exogenous GH increases linear growth velocity (LGV). The present study determined the effect of exogenous GH treatment on LGV, the dose(s) of exogenous GH that effectively impacts LGV and the stage(s) of puberty at which the effect of exogenous GH treat...

ea0035p685 | Male reproduction | ECE2014

An analysis of the possible relationship circulating concentrations of ghrelin, LH, FSH, testosterone and inhibin B at the time of puberty in normal healthy boys

Naseem A A , Rizvi S S R , Anwer Urooj , Mehmood Sana , Perveen Nadia , Shaheen Ghazala , Saqib Sadia , Tahir Faheem , Qayyum Mazhar

Ghrelin receptor GHSR1α is expressed in hypothalamo–pituitary–gonadal tissues. Ghrelin reduces GnRH secretion in pre-pubertal period and concentrations of ghrelin are positively correlated with testosterone at adulthood. Nevertheless, the role of ghrelin in affecting pituitary and gonadal functions during normal pubertal development remains elusive. A possible correlation between ghrelin and LH, FSH, testosterone and inhibin B was examined in boys (n=55...