Endocrine Abstracts

Type 1 diabetes mellitus (T1DM), typically emerging in childhood, is an autoimmune condition where T cells destroy insulin-producing islet β cells in the pancreas. Chronic hyperglycemia from diabetes results in significant organ damage, including the kidneys, eyes, nerves, heart, and blood vessels. The study of plasma-free amino acids (PFAA) profiles in T1DM within the Jordanian population is scant and not well-documented. This research analyzed the PFAA profiles in Jorda...

Lifestyle-related disorders such as metabolic syndrome, diabetes mellitus (DM), dyslipidemia, and hypertension are key contributors to cardiovascular diseases. The interplay of diabetes and hypertension significantly affects the progression of atherosclerotic cardiovascular disease. Amino acids vary chemically based on their side chains, classifying them into acidic, basic, and neutral groups. Alterations in amino acid metabolism are critically involved in disease pathogenesis...

Background: Diabetes mellitus type 2 (T2D) is a prevalent metabolic disorder characterized by insulin resistance and high blood sugar levels. Existing treatments focus on managing these symptoms, but there is an ongoing need for more effective interventions. Our study explores the potential of 2′,3,3,5′-Tetramethyl-4′-nitro-2′H-1,3′-bipyrazole (TMNB) in this context, based on its presumed impact on oxidation, glycation, and insulin resistance proc...