Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep477 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lack of postpartum reclassification test in gestational diabetes – factors conditioning loss of follow-up

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Queiros Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for maternal-fetal complications and development of diabetes or intermediate hyperglycemia after pregnancy. The follow-up should be done by a multidisciplinary team. After delivery, all women diagnosed with GDM should undergo an oral glucose tolerance test (OGTT) for reclassificationAim: To evaluate the non-adherence factors to reclassification OGTT after GDM.Method...

ea0032p783 | Obesity | ECE2013

Madelung's disease: a case report

Jorge Georgina , Queiros Joana , Mequista Joana , Oliveira Ana , Silva Pedro , Carvalho Davide

Introduction: Madelung’s disease is a rare disorder characterized by a disturbance in the adipocyte metabolism. Mainly occurs in alcoholic Mediterranean male, presenting multiple, symmetrical lipomas.Case report: A 49-year-old obese man with a history of alcoholism, complaint of weight gain, soft and slow-growing swelling of the neck, and shoulders. His past history: epilepsy, alcoholic CHD, hypothyroidism, severe sleep apnea, vitiligo and HTA. His ...

ea0099p380 | Thyroid | ECE2024

Interrelationships between thyroid function, autoimmunity, low-grade inflammation, lipid profile and insulin resistance in graves’ disease

Neves Celestino , Sergio Neves Joao , Miguel Pereira Luis , Sokhatska Oksana , Queiros Joana , Luis Delgado Jose

Aim: The aim of this study was to evaluate the association between thyroid function in Graves’ disease (GD) with high-sensitivity C-reactive protein (hs-CRP), lipid profile, homocysteine, folate, vitamin B12 and insulin resistance.Methods: We performed a cross-sectional of 104 patients with recently diagnosed GD. All participants were in the first cycle of treatment with methimazole. We collected demographic information, body mass indexes (BMI), lab...

ea0099ep716 | Pituitary and Neuroendocrinology | ECE2024

Acromegaly and adrenal myelolipoma - Is there a connection?

Menino Joao , Meira Ines , Ribeiro Sara , Goncalves Juliana , Pedro Jorge , Queiros Joana

Introduction: Adrenal myelolipomas are rare benign tumors. There has been an association of adrenal myelolipomas with other pathologies with hormonal hypersecretion, such as hypersecretion of adrenocortical hormone (ACTH) in Cushing’s Disease and Congenital adrenal hyperplasia. We report a case of acromegaly with co-existent large adrenal myelolipoma.Case Report: A 48-year-old caucasian male was referred to our Endocrinology consultation for an adre...

ea0099ep838 | Thyroid | ECE2024

Intra-Thyroid metastases of clear cell renal carcinoma - analysis of two complex cases

Ribeiro Sara , Goncalves Juliana , Carlos Almeida Joao , Varela Ana , Queiros Joana

Introduction: Intra-thyroid metastases are infrequent, comprising only 1-3% of all thyroid malignancies. Renal cell carcinoma, particularly of the clear cell type (CCRC), stands out as the predominant kidney malignancy and the most common primary source of intra-thyroid metastases, often manifesting several years post-diagnosis. This report highlights two cases of CCRC metastasis to the thyroid, both featuring deceptive cytological findings.Case 1: A 60-...

ea0049ep773 | Clinical case reports - Thyroid/Others | ECE2017

Nivolumab-associated pituitary, adrenal and thyroid autoimmune disorders

Bettencourt-Silva Rita , Oliveira Joana , Esteves Cesar , Hespanhol Venceslau , Fernandes Gabriela , Caeiro Claudia , Queiros Joana , Carvalho Davide

Background: Nivolumab is a monoclonal antibody specific for human PD-1 (programmed cell death protein-1), a checkpoint molecule highly expressed in several cancers. Nivolumab is an immunotherapeutic strategy for human cancer, but it can interfere with endocrine system.Case reports: We report four cases regarding nivolumab-associated endocrinopathies: (i) Male, 55-year-old, with previous normal cortisol and adrenocorticotropic hormone (ACTH) levels, treat...

ea0041ep282 | Clinical case reports - Pituitary/Adrenal | ECE2016

Cyclic Cushing’s syndrome – a diagnostic challenge

Magalhaes Daniela , Bettencourt-Silva Rita , Queiros Joana , Freitas Paula , Vinha Eduardo , Pignatelli Duarte , Pereira Josue , Carvalho Davide

Introduction: The diagnosis of Cushing’s syndrome is often challenging considering that none of the used laboratory tests has an ideal diagnostic accuracy. The complexity of the diagnosis increases in cyclic disorder, which is characterized by repeated episodes of cortisol excess followed by periods of normal cortisol secretion.Case report: A 32-year-old woman with history of arterial hypertension and obesity presented with weight gain, hirsutism, a...

ea0041ep634 | Endocrine tumours and neoplasia | ECE2016

Hypoglycaemia unawareness – a challenge in the management of a Von Hippel-Lindau patient

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Oliveira Joana , Bessa de Melo Renato , Costa Maia Jose , Carvalho Davide , Queiros Joana

Background: The key physiologic defences against hypoglycaemia are the decrease in insulin and the increased secretion of glucose counterregulatory hormones, namely glucagon and epinephrine. The absence of warning signs of impending neuroglycopenia is known as hypoglycaemic unawareness.Case report: Male, 26 year-old, without relevant medical history and with normal body mass index, presented with hypertension, palpitations and diaphoresis. Clinical suspi...

ea0020p281 | Clinical case reports and clinical reports | ECE2009

Amiodarone-induced thyrotoxicosis – case report

Souto Selma B , Matos Maria J , Freitas Paula , Queiros Joana , Magalhaes Angela , Carvalho-Braga Daniel , Medina Jose Luis

Introduction: Amiodarone-induced thyrotoxicosis(AIT) is a condition fraught with difficulties from the diagnostic and therapeutic standpoints. It can be developed precociously or years after the beginning amiodarone uptake and after its suspension. AIT is subdivided in three different forms. Type 1 is developed in subjects with underlying thyroid disease, being caused by an exacerbation by iodine load of thyroid autonomous function. Type 2 is a form of destructive thyroiditis ...

ea0049ep564 | Diabetes complications | ECE2017

Small for gestational age and gestational diabetes – Should we be more permissive?

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for large for gestational age (LGA) newborns. The optimization of glycemic control and weight gain restriction during pregnancy according to BMI has contributed to decrease LGA but may increase the risk of small for gestational age (SGA).Aim: To evaluate the predictors of SGA in women with DGM.Methods: A cohort of 5271 Portuguese women from the National Registry of ...