Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep477 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Lack of postpartum reclassification test in gestational diabetes – factors conditioning loss of follow-up

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Queiros Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for maternal-fetal complications and development of diabetes or intermediate hyperglycemia after pregnancy. The follow-up should be done by a multidisciplinary team. After delivery, all women diagnosed with GDM should undergo an oral glucose tolerance test (OGTT) for reclassificationAim: To evaluate the non-adherence factors to reclassification OGTT after GDM.Method...

ea0032p783 | Obesity | ECE2013

Madelung's disease: a case report

Jorge Georgina , Queiros Joana , Mequista Joana , Oliveira Ana , Silva Pedro , Carvalho Davide

Introduction: MadelungÂ’s disease is a rare disorder characterized by a disturbance in the adipocyte metabolism. Mainly occurs in alcoholic Mediterranean male, presenting multiple, symmetrical lipomas.Case report: A 49-year-old obese man with a history of alcoholism, complaint of weight gain, soft and slow-growing swelling of the neck, and shoulders. His past history: epilepsy, alcoholic CHD, hypothyroidism, severe sleep apnea, vitiligo and HTA. His ...

ea0049ep773 | Clinical case reports - Thyroid/Others | ECE2017

Nivolumab-associated pituitary, adrenal and thyroid autoimmune disorders

Bettencourt-Silva Rita , Oliveira Joana , Esteves Cesar , Hespanhol Venceslau , Fernandes Gabriela , Caeiro Claudia , Queiros Joana , Carvalho Davide

Background: Nivolumab is a monoclonal antibody specific for human PD-1 (programmed cell death protein-1), a checkpoint molecule highly expressed in several cancers. Nivolumab is an immunotherapeutic strategy for human cancer, but it can interfere with endocrine system.Case reports: We report four cases regarding nivolumab-associated endocrinopathies: (i) Male, 55-year-old, with previous normal cortisol and adrenocorticotropic hormone (ACTH) levels, treat...

ea0041ep282 | Clinical case reports - Pituitary/Adrenal | ECE2016

Cyclic Cushing’s syndrome – a diagnostic challenge

Magalhaes Daniela , Bettencourt-Silva Rita , Queiros Joana , Freitas Paula , Vinha Eduardo , Pignatelli Duarte , Pereira Josue , Carvalho Davide

Introduction: The diagnosis of CushingÂ’s syndrome is often challenging considering that none of the used laboratory tests has an ideal diagnostic accuracy. The complexity of the diagnosis increases in cyclic disorder, which is characterized by repeated episodes of cortisol excess followed by periods of normal cortisol secretion.Case report: A 32-year-old woman with history of arterial hypertension and obesity presented with weight gain, hirsutism, a...

ea0041ep634 | Endocrine tumours and neoplasia | ECE2016

Hypoglycaemia unawareness – a challenge in the management of a Von Hippel-Lindau patient

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Oliveira Joana , Bessa de Melo Renato , Costa Maia Jose , Carvalho Davide , Queiros Joana

Background: The key physiologic defences against hypoglycaemia are the decrease in insulin and the increased secretion of glucose counterregulatory hormones, namely glucagon and epinephrine. The absence of warning signs of impending neuroglycopenia is known as hypoglycaemic unawareness.Case report: Male, 26 year-old, without relevant medical history and with normal body mass index, presented with hypertension, palpitations and diaphoresis. Clinical suspi...

ea0020p281 | Clinical case reports and clinical reports | ECE2009

Amiodarone-induced thyrotoxicosis – case report

Souto Selma B , Matos Maria J , Freitas Paula , Queiros Joana , Magalhaes Angela , Carvalho-Braga Daniel , Medina Jose Luis

Introduction: Amiodarone-induced thyrotoxicosis(AIT) is a condition fraught with difficulties from the diagnostic and therapeutic standpoints. It can be developed precociously or years after the beginning amiodarone uptake and after its suspension. AIT is subdivided in three different forms. Type 1 is developed in subjects with underlying thyroid disease, being caused by an exacerbation by iodine load of thyroid autonomous function. Type 2 is a form of destructive thyroiditis ...

ea0049ep564 | Diabetes complications | ECE2017

Small for gestational age and gestational diabetes – Should we be more permissive?

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Belo Sandra , Oliveira Ana , Carvalho Davide , Queiros Joana , Diabetes and Pregnancy Study Group Portuguese Society of Diabetology

Introduction: Gestational diabetes mellitus (GDM) is a risk factor for large for gestational age (LGA) newborns. The optimization of glycemic control and weight gain restriction during pregnancy according to BMI has contributed to decrease LGA but may increase the risk of small for gestational age (SGA).Aim: To evaluate the predictors of SGA in women with DGM.Methods: A cohort of 5271 Portuguese women from the National Registry of ...

ea0049ep576 | Diabetes complications | ECE2017

Severe diabetic gastroparesis – two cases of challenging treatment

Souteiro Pedro , Oliveira Sofia Castro , Neves Joao Sergio , Santos-Antunes Joao , Bettencourt-Silva Rita , Belo Sandra , Neves Celestino , Freitas Paula , Queiros Joana , Esteves Cesar , Carvalho Davide

Introduction: Gastroparesis is defined by a delayed gastric emptying without mechanical obstruction. It can be a debilitating complication of diabetes that is poorly understood and has limited therapeutic options.Case reports: 1st case - We report the case of a 34-year-old woman with type 1 diabetes mellitus (T1DM) with diabetic nephropathy and gastroparesis, and a reasonable glycaemic control...

ea0049ep630 | Diabetes therapy | ECE2017

Determinants of patient’s adherence and its relation to therapeutic success after hospital admission for decompensated diabetes

Magalhaes Daniela , Saavedra Ana , Souteiro Pedro , Bettencourt-Silva Rita , Costa Maria Manuel , Castedo Jose Luis , Freitas Paula , Nogueira Claudia , Queiros Joana , Carvalho Davide

Introduction: Diabetes mellitus (DM) is a chronic disease that requires continuous medical care. Health care providers should adopt approaches that improve patient outcomes and adherence.Aims: To evaluate the adherence to Endocrinology ambulatory follow-up after elective hospital admission for decompensated DM and to determine the relationship between adherence and therapeutic success after discharge.Methods: Retrospective study of...

ea0041ep328 | Clinical case reports - Thyroid/Others | ECE2016

Diabetic gastroparesis – a pregnancy in jeopardy

Magalhaes Daniela , Bettencourt-Silva Rita , Costa Maria Manuel , Saavedra Ana , Belo Sandra , Queiros Joana , Freitas Paula , Namora Gabriela , Montenegro Nuno , Carvalho Davide

Introduction: Diabetic gastroparesis (DGP) is defined by delayed gastric emptying in the absence of mechanical obstruction caused by autonomic neuropathy. Only 5% of type 1 and 1% of type 2 diabetic patients combine the delay of gastric emptying with typical gastroparesis symptoms. This entity is usually identified in patients with least 10 years of diabetes evolution and is presented typically in the 4th to 5th decades of life in type 1 diabetes mellitus (T1DM). It is associa...