Endocrine Abstracts

BackgroundPreliminary in vivo studies have shown that fatty acid composition of membranes, where insulin receptors are embedded, can provide significant correlations for insulin resistance. Docosahexaenoic acid (DHA) is a member of the n-3 polyunsaturated fatty acid family present in the membrane that may modulate insulin action. The aim of the study was to investigate if variation in insulin sensitivity is related to variation in DHA in red blood...

ObjectiveTo examine the relationship between leptin, adiponectin and insulin resistance in a group of men and women with varying degrees of glucose tolerance and obesity.Method69 participants were investigated and divided into four groups: 15 normal weight with normal glucose tolerance (NW NGT); 22 overweight with normal glucose tolerance (OW NGT); 15 overweight with impaired glucose tolerance (OW IGT); and 1...

Growth hormone (GH) has profound anabolic effects on bone, but its use as a treatment for patients with osteoporosis has only resulted in small increases in BMD. The low serum IGF-I demonstrated in men with idiopathic osteoporosis may be important in the aetiology of this disease and has been attributed to GH hypo-secretion, though there are conflicting reports of this. Insensitivity to the actions of GH has also been suggested. We studied the GH-IGF-I axis in otherwise health...