ea0029s4.2 | The gut nutrient sensing in energy metabolism | ICEECE2012
Margolskee R.
We have found that many of the receptors and downstream signalling elements involved in taste detection and transduction are expressed also in intestinal hormone producing (endocrine) cells where they underlie key chemosensory functions of the gut. In one example of gastrointestinal chemosensation it is known that glucose given orally, but not systemically, induces secretion of the incretin hormone glucagon like peptide-1 (GLP-1), which in turn regulates insulin se...