Searchable abstracts of presentations at key conferences in endocrinology

ea0029s4.2 | The gut nutrient sensing in energy metabolism | ICEECE2012

Taste receptors in gut regulate endocrine function

Margolskee R.

We have found that many of the receptors and downstream signalling elements involved in taste detection and transduction are expressed also in intestinal hormone producing (endocrine) cells where they underlie key chemosensory functions of the gut. In one example of gastrointestinal chemosensation it is known that glucose given orally, but not systemically, induces secretion of the ‘incretin’ hormone glucagon like peptide-1 (GLP-1), which in turn regulates insulin se...