Searchable abstracts of presentations at key conferences in endocrinology

ea0029s17.1 | Hormonal control of pregnancy | ICEECE2012

Hormone signalling between mother and fetus

Reynolds R.

The developing fetus adapts to an adverse in utero environment, and is ‘programmed’ to an increased risk of developing disease in later life. Fetal growth is regulated via a complex interplay between mother, placenta and fetus. Maternal nutrients, transported via the placenta, are essential for fetal growth. Conversely, the placenta may also respond to fetal endocrine signals to regulate maternal metabolism. The placenta also regulates fetal growth via production and...

ea0024oc2.2 | Oral Communications 2 (Brief Communications) | BSPED2010

An unbalanced maternal diet in pregnancy is associated with epigenetic effects in the offspring

Drake A , Knox R , Seckl J , Reynolds R

Epigenetic dysregulation may be one mechanism underpinning the link between early life conditions and later cardiometabolic risk. In animal models, environmental manipulations including modified maternal diet change DNA methylation and offspring phenotype. Manipulations altering the epigenetic state reverse the phenotype suggesting causality. We have previously reported higher blood pressure (BP) and cortisol in an adult cohort whose mothers were advised to eat a high-protein,...

ea0019p327 | Steroids | SFEBES2009

Measuring cortisone production in man using a new stable isotope tracer

Hughes K A , Reynolds R M , Andrew R , Walker B R

Background: 11β-hydroxysteroid dehydrogenases (11β-HSD1&2) interconvert cortisol (F) and cortisone (E). Although 11β-HSD1 reductase activity has been measured in vivo, E production (dehydrogenase activity) has not been quantified using a Gold Standard technique, steady state tracer infusion.Aim: To develop a method to measure E production in vivo using the stable isotope tracer d2-cortisone (d2E).Me...

ea0019p150 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Kisspeptin inhibits key stages of angiogenesis in vitro

Logie J , Roseweir A , Millar R , Walker B , Hadoke P , Reynolds R

Background: Kisspeptin is a neuropeptide central to the regulation of gonadotrophin secretion but recent studies have suggested more diverse roles in human physiology. Kisspeptin is a potent inhibitor of tumour metastasis and plays a role in placentation, both processes involving angiogenesis. In addition, Kisspeptin and its receptor, GPR54, have been identified in human blood vessels including aorta, coronary artery and umbilical vein, where they mediate vasoconstriction. We,...

ea0009p27 | Diabetes and metabolism | BES2005

Maternal consumption of a high-meat, low carbohydrate diet during pregnancy impairs glucose tolerance in the adult offspring

Reynolds R , Godfrey K , Haselden S , Sheill A , Barker D , Campbell-Brown M , Phillips D

There is evidence that an unbalanced maternal diet, combining a high ratio of protein to carbohydrate with low intakes of folate and green vegetables imposes a metabolic stress on the mother and fetus leading to fetal growth retardation. Because recent studies have shown that high protein maternal diets are associated with raised offspring blood pressure, we have assessed whether this form of unbalanced maternal nutrition is also associated with glucose intolerance.<p clas...

ea0005p228 | Steroids | BES2003

Activation of the hypothalamic-pituitary-adrenal axis in adult women with low birthweight

Reynolds R , Walker B , Syddall H , Andrew R , Wood P , Phillips D

Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis in men of low birthweight may be an important link between early life events and adult metabolic syndrome. In animal models females are more sensitive to HPA axis programming by manipulations in utero, but whether gender influences susceptibility in humans is unknown.We studied 106 women aged 67-78 y, from Hertfordshire UK, in whom birthweight was recorded. None had pituitary or adrenal disease or were rec...

ea0005p232 | Steroids | BES2003

Urinary 18-hydroxycortisol: diagnostic utility of three methods compared

Reynolds R , Sandhu K , Shakerdi L , Wallace A , Wood P , Walker B

Urine 18-hydroxy cortisol ('18OHF') measurements are claimed to have the potential to discriminate between primary hyperaldosteronism due to either Conn's syndrome/adrenal adenoma (increased values) or idiopathic adrenal hyperplasia (normal values), and also to identify cases of glucocorticoid-suppressible hyperaldosteronism ('GSH').We have evaluated three urine 18-OHF methods using a panel of samples from patients with primary hyperaldosteronism [due to either adenoma (N=...

ea0065op5.1 | Reproductive Endocrinology and Biology | SFEBES2019

Hypothalamic-pituitary-gonadal (HPG) axis suppression during basic military training in women despite increased adiposity and insulin resistance

Gifford Robert M , O'Leary Thomas J , Wardle Sophie L , Greeves Julie P , Anderson Richard A , Woods David R , Reynolds Rebecca M

Background: Low energy availability (LEA) in female athletes can result in HPG axis suppression. Basic military training (BMT) is physically arduous and associated with amenorrhoea and low-trauma fractures. We hypothesised that women undergoing BMT would demonstrate evidence of LEA and suppressed HPG function.Design: Prospective study of 61 women undertaking 11-month BMT. Subjects acted as their own controls at baseline (all measures). Body composition m...

ea0009oc35 | Oral Communication 5: Thyroid | BES2005

Risk of second cancers among people with thyroid cancer - treatment effects or common aetiology?

Sandeep T , Strachan M , Reynolds R , Brewster D , Scelo G , Pukkala E , Hemminki K , Anderson A , Tracey E , Friis S , McBride M , Kee-Seng C , Pompe-Kirn V , Kliewer E , Tonita J , Jonasson J , Martos C , Boffetta P , Brennan P

BackgroundIncreasing incidence of thyroid cancer together with improved prognosis raises a concern regarding development of second primary cancers. Moreover, little is known about the incidence of thyroid cancer as a second primary neoplasm after other cancers.MethodsA cohort of 39002 people (356034.5 person years) with primary thyroid cancer was identified in 13 population-based cancer registries in Europe, ...