Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1134 | Late Breaking | ECE2023

An interplay between primary hyperparathyroidism, Hashimoto thyroidis and thyroid cancer

Sparavalo Rada , Borozan Sanja

The incidence of well differentiated thyroid carcinoma (TC), mostly papillary, is higher among patients with primary hyperparathyroidism (PHPT) compared to the general population, despite the similar frequency of thyroid nodules. The link between TC and Hashimoto thyroiditis (HT) is attributed to chronic inflammation, but the molecular association is poorly undestood. Herein, we explore the possible interplay between HT, PHPT and papillary TC through a case report and a litera...

ea0063p836 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A germline ARMC5 mutation in a patient with adrenal adenoma and multiple colonic polyps: a case report

Sparavalo Rada , Borozan Sanja

Background: Functional studies demonstrate that Armadillo repeat-containing 5 (ARMC5) gene, controls apoptosis and steroid synthesis. A germline mutations in ARMC5 are recently been associated with Cushing syndrome and possibly can be responsible for a broader tumor predisposition.Case presentation: A 51-year-old woman presented with intermittent rectal bleeding. A colonoscopy revealed multiple colonic polyps, histopathological analysis showed tubular ad...

ea0070aep558 | General Endocrinology | ECE2020

Delay in diagnosis and clinical course of autoimmune polyglandular syndrome

Sparavalo Rada , Borozan Sanja

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...

ea0070ep53 | Adrenal and Cardiovascular Endocrinology | ECE2020

Delayed diagnosis of Cushing’s syndrome

Sparavalo Rada , Borozan Sanja

Because of quite variable clinical manifestations of Cushing’s syndrome and overlap with more common medical problems, its diagnosis is frequently mistaken, with consequent considerable delay from the first presentation to a different primary and secondary care physicians to a final diagnosis, often made by endocrinologist. The diagnostic latency in reported studies vary from six months to ten years. We report a case of a 54-years-old female admitted to the hospital thro...

ea0070ep284 | Pituitary and Neuroendocrinology | ECE2020

Secondary amenorrhea and large uterine myomas in a patient with acromegaly

Borozan Sanja , Sparavalo Rada

Menstrual irregularity is common in women with acromegaly, occurring in 40–84% of patients. Its pathogenesis is still not well established although it is usually attributed to prolactin excess and/or gonadotropin deficiency. Also, since the presence of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors is demonstrated in the myometrium, a pathogenetic role of GH in the development of myoma is examined through different studies. Moreover, some of them ...

ea0073aep605 | Reproductive and Developmental Endocrinology | ECE2021

Primary amenorrhea due to hypogonadotropic hypogonadism

Sparavalo Rada , Borozan Sanja

A diagnosis of primary amenorrhea (PA) is always a clinical challenge. By definition, PA is a failure to reach menarche by age 14 with the absence of secondary sexual characteristics or absence of menses by age 16 years regardless of the development of secondary sexual characteristics. It may result from a number of different conditions and requires comprehensive evaluation to identify a cause, along with a regular patient follow-up. The aim of this case report is to emphasize...

ea0093p14 | Guided Poster Tour 2: Miscellaneous | EYES2023

Assessment of knowledge and awareness of disease in patients with diabetes

Vasiljevic Luka , Sparavalo Rada

Introduction and objective: The research was conducted with the aim of highlighting the awareness and understanding of the disease among diabetic patients.Methods: The study included 85 patients with type 2 diabetes, aged 40+ years old, who had been monitoring their blood glucose levels and HbA1c levels in the previous 4 months. Patients were presented a questionnaire with 5 questions about diabetes. The patients’ responses were classified and expre...

ea0073aep513 | Pituitary and Neuroendocrinology | ECE2021

Growth hormone deficiency in hypopituitary male patient with treated Cushing’s disease

Borozan Sanja , Sparavalo Rada , Vrbica Sanja

Impaired growth hormone (GH) secretion occurs in patients with Cushing’s disease (CD) as a result of cortisol excess. After a surgical treatment, eventually accompanied with radiation therapy, recovery of GH secretion is seen in only variable proportion of patients. According to some studies, it is recommended to perform assessment of GH secretion one to two years after surgical cure of CD. We report a case of a 40-years-old male admitted to the hospital because of sudden...

ea0099ep715 | Pituitary and Neuroendocrinology | ECE2024

Deep vein thrombosis unmasking the diagnosis of Sheehan syndrome

Sparavalo Rada , Borozan Sanja , Vrbica Sanja

Sheehan syndrome (SS) caused by postpartum hemorrhage leads to varying degrees of pituitary insufficiency. With improved obstetrical care, ischemic pituitary necrosis is less common and, as a consequence, most cases of SS are being overlooked and diagnosis is delayed for years due to its nonspecific signs and symptoms. Data regarding the relationship between hypopituitarism and increased risk of venous thrombosis are inconsistent and need to be elucidated further. A 41-years-o...

ea0063p577 | Diabetes, Obesity and Metabolism 2 | ECE2019

Comparison of effects of metformin used as a monotherapy or in combination with gliclazide MR on glycemic control and lipid profile in patients with type 2 diabetes mellitus

Vujosevic Snezana , Borozan Sanja , Kavaric Sreten , Boskovic Olivera , Krnjevic Djordjije , Cikic Elzana , Muzurovic Emir , Bjeladinovic Igor , Radovanic Snezana , Sparavalo Rada , Vukicevic Violeta , Ivanovic Suzana , Pupovic Enisa

Objective: To evaluate and compare the effects of metformin used as a single-agent therapy and in combination with gliclazide modified release (MR) on glycoregulation and lipid profile in patients with type 2 diabetes mellitus (T2DM).Methodology: A multi-center observational epidemiological study was carried out in patients with T2DM, divided in two groups according to the current type of treatment: first group was on monotherapy with metformin in daily ...