Searchable abstracts of presentations at key conferences in endocrinology

ea0015p6 | Bone | SFEBES2008

Sunlight deficiency: a reversible cause of low serum phosphate?

Chambers Thomas , Heald Adrian , Radford Daniela , Waldron Julian , Davies Marten , Baines Malcolm

Background: Vitamin D3 is generated in the skin of humans from 7-dehydrocholesterol by ultraviolet light. Vitamin D3 is hydroxylated to its metabolically active form in the liver and kidneys. The hydroxylated form of Vitamin D3, is required for both phosphate and calcium absorption in the gut and reabsorption from the kidneys. Vitamin D deficiency is associated with a low circulating calcium and phosphate.Case report: A 5...

ea0015p242 | Pituitary | SFEBES2008

Macroprolactin: role of serial measurement through pregnancy

Nair Sunil , Blantern Liz , Radford Daniela , Davies Marten , Kane John , Heald Adrian

Background: Recent studies have indicated that macroprolactinaemia accounts for up to 26% of biochemical hyperprolactinaemia depending on the assay in use. Delayed metabolic clearance of macroprolactin together with detection by most automated prolactin immunoassay systems leads to pseudo-hyperprolactinemia in patients harbouring this form of complexed prolactin.We here describe the use of serial macroprolactin measurement to assist in the management of ...

ea0015p252 | Pituitary | SFEBES2008

Adjustment for macroprolactin: an integral part of laboratory assessment of hyperprolactinaemia

Blantern Liz , Qureshi Zubair , Heald Adrian , Anderson Simon , Radford Daniela , Waldron Julian , Davies Marten , McCulloch Alan , Kane John

Background: In most people, prolactin circulates predominantly as a 23-kDa monomer, and a high-molecular-weight form which in the vast majority of cases consists of a complex of prolactin and an anti-prolactin IgG autoantibody, commonly referred to as macroprolactin. This cross-reacts with conventional laboratory assays for prolactin.Report: In a consecutive series of 218 patients with prolactin elevated to 400 μ/l or more in men (normal range &#880...