Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1099 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary apoplexy (PA) – a relatively rare condition requiring early recognition, individualized treatment and longterm follow-up

Vladan Andreea , Baranga Iuliana , Niculescu Dan , Radian Serban , Radian Serban , Poiana Catalina

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

ea0034p314 | Pituitary | SFEBES2014

Analysis of the AIP gene promoter

Radian Serban , King Peter , Korbonits Marta

Background: Germline mutations of the AIP tumour suppressor gene are associated with familial and sporadic pituitary adenomas, yet the tumorigenic mechanisms remain unclear. In addition, AIP protein expression in somatotroph adenomas from patients without AIP mutations correlates with clinical behaviour and somatostatin analogues responsiveness. Understanding the regulation of AIP gene expression will help uncover its pituitary tumour-suppressor role.Aim...

ea0049ep1067 | Pituitary - Clinical | ECE2017

Nonfunctioning pituitary incidentaloma – delayed onset of acromegaly and concomitant primary adrenocortical insufficiency

Radian Serban , Deciu Diana , Lefter Antonia , Poiana Catalina

Introduction: Pituitary incidentaloma (PitInc), defined as an unsuspected mass observed on imaging studies performed for unrelated conditions. Most such lesions are not clinically significant at initial evaluation and current guidelines recommend periodic follow-up.Aim: To present a rare case of delayed onset of acromegaly in a patient with a nonfunctioning PitInc, raising the question of the utility of prolonged follow-up of PitInc.<p class="abstext...

ea0037ep197 | Reproduction, endocrine disruptors and signalling | ECE2015

The connection between serum prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

ea0070aep633 | Pituitary and Neuroendocrinology | ECE2020

ACTH-secreting pituitary tumor with delayed aggressive clinical recurrence – management challenges

Gaita Isabela , Cristescu Alexandru , Enculescu Augustina , Poiana Catalina , Radian Serban

Background: Pituitary adenomas (PA) are slow-growing, benign intracranial tumors. Rarely, they can be histologically and clinically aggressive.Aim: To present a case of corticotroph PA with aggressive behavior following a long indolent interval after the initial surgery.Case presentation: A 47 years old female presented in Nov 2007 with right temporal hemianopsia and left eye blindness, associating type 2 DM and severe mixed dyslip...

ea0031p169 | Neoplasia, cancer and late effects | SFEBES2013

Between genetics, guidelines and treatment in MEN2A: a family affair

Dobrescu Ruxandra , Hortopan Dan , Stanescu Bogdan , Radian Serban , Badiu Corin

The multiple endocrine neoplasia syndrome type 2A (MEN 2A) is the consequence of a heritable mutation in the RET proto-oncogene, leading to a very high predisposition to develop medullary thyroid carcinoma (MTC), pheochromocytoma and primary parathyroid hyperplasia. Screening of ‘at-risk’ family members and prophylactic thyroidectomy is recommended – but not always easily accomplished.Our proband was diagnosed with MTC in 1977 (at age 21),...

ea0065p64 | Adrenal and Cardiovascular | SFEBES2019

Primary aldosteronism (PA) – clinical and hormonal characteristics of a series of patients

Vladan Andreea , Baranga Iuliana , Dumitrascu Anda , Hortopan Dan , Poiana Catalina , Radian Serban

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of hypertensive patients diagnosed with PA, biochemical screening (aldosterone:renin ratio/ARR), confirmatory tests, and adrenal CT results.Methods: Clinical, hormonal and imaging evaluation.Results: 13 patients (7M/6F) with PA were 45 yrs (40&#1...

ea0067gp16 | Poster Presentations | EYES2019

Association of adrenal cortisol-producing adenoma and invasive papillary thyroid carcinoma in an older patient: coincidence or multiple endocrine neoplasia (MEN)?

Iancu Cristina , Gaita Isabela , Tomulescu Victor , Iorgulescu Radu , Capatina Cristina , Radian Serban , Poiana Catalina

Background: Association of differentiated thyroid carcinoma (DTC) and cortisol-producing adrenal adenoma is not part of the classical MEN syndromes. We present a clinical case raising the question of a common etiology for these tumours.Case Presentation: A 58-year-old female presented in 2010 for the investigation of a 6 cm left adrenal tumour incidentally discovered by abdominal CT. Medical history included smoking, obesity, myocardial infarction, hyper...

ea0063p852 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Multiple paragangliomas (PGs) of head and neck and middle mediastinum: report of an apparently sporadic case

Maria Baranga Iuliana , Vladan Andreea , Vasilescu Alexandru , Serban Marinela , Stoleru Liviu , Radian Serban , Poiana Catalina

Introduction: PGs are rare neuroendocrine tumours (NETs), slowly growing, derived from the neural crest cells of the autonomous nervous system. Presenting symptoms are related to catecholamine hypersecretion or to mass effect. The optimal approach is dictated by size, symptoms and anatomical relationship of tumours with neurovascular structures.Aim: To describe a patient with bilateral carotid body and mediastinal carotid body PGs....

ea0059p203 | Thyroid | SFEBES2018

Characterization of thyroid nodules in acromegalic patients

Trifanescu Raluca , Galoiu Simona , Niculescu Dan , Baciu Ionela , Capatina Cristina , Radian Serban , Poiana Catalina

Background: Thyroid nodules were reported with high prevalence in acromegalic patients.Patients and methods: 63 acromegalic patients (16 males and 47 females), aged at diagnosis 43.6±12.7 years were retrospectively reviewed. Median duration of acromegaly was 8 years. 25 patients were residents in iodine deficient areas. GH, IGF1, TSH, FT4 were measured by chemiluminescence (Liaison). Thyroid ultrasound was performed. In suspected nodules,...