Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep614 | Endocrine tumours and neoplasia | ECE2016

Nestin and Klotho protein expression in neuroendocrine tumors of the lung

Bromińska Barbara , Gabryel Piotr , Jarmołowska-Jurczyszyn Donata , Kluk Andrzej , Woliński Kosma , Trojanowski Maciej , Czepczyński Rafał , Dyszkiewicz Wojciech , Ruchała Marek

Introduction: Neuroendocrine tumors of the lungs comprise 20% of primary lung tumors. Nestin is an intermediate filament protein, expressed in stem cells during fetal development. It is also described as a potential cancer stem cell marker, angiogenesis marker and indicator of poorer survival probability for patients with some types of malignancies. Adversely, Klotho gene is a potential tumor suppressor. Aberrant expression of Klotho have been recently noticed in a number of c...