Searchable abstracts of presentations at key conferences in endocrinology

ea0063p456 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

An investigation into the role of parathyroid hormone in the regulation of aldosterone secretion in hypertensive cardiovascular patients

Jannat Saba , Akram Maleeha , Jahan Sarwat , Kazmi Ali Raza , Afshan Kiran , Tahir Fahim , Naseem Afzaal Ahmed , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Hypertension or elevated blood pressure (BP) is quantitatively the most important risk factor for development of cardiovascular diseases (CVDs), whereas aldosterone contributes significantly in the development and severity of hypertension. Interestingly, parathyroid hormone (PTH) stimulates aldosterone synthesis by regulating renin-angiotensin-aldosterone system (RAAS). Conversely, RAAS controls PTH secretion, as angiotensin receptor is expressed by human parathyroid tissues a...

ea0063p892 | Diabetes, Obesity and Metabolism 3 | ECE2019

An investigation into the relationship between plasma concentrations of cortisol, testosterone, blood pressure and blood glucose levels in diabetic hypersensitive cardiovascular patients

Ullah Safir , Rafi Muhammad , Akram Maleeha , Kazmi Ali Raza , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

Diabetes mellitus type 2 (DM-2) occurs when pancreas fails to produce enough insulin or when the body cannot effectively make use of the insulin produced by the pancreas. Among other factors causing DM-2, stress is increasingly regarded as one of the causative agents that make the blood glucose levels rise, and cause DM-2. It has also been reported that DM-2 may be one of the commonest cause of hypogonadism, a lack of function in the testes, which adversely affects testosteron...

ea0063ep3 | Adrenal and Neuroendocrine Tumours | ECE2019

Depression and anxiety are positively correlated with higher concentrations of cortisol and blood pressure in hypertensive cardiovascular disease patients

Unab Shiza , Akram Maleeha , Tahir Fahim , Jahan Sarwat , Kazmi Ali Raza , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Hypertension or high blood pressure (HBP) has been counted as the chief cause and most significant factor in the development of cardiovascular diseases (CVDs) worldwide. Stress has been defined as an inner process that happens when a person is faced with an ordinant dictation that is perceived to go beyond the resources available to efficaciously respond to it. Cortisol is a hormone released from the zona fasciculata of the adrenal cortex during the times of stress. This biolo...

ea0070aep270 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

A comparison of the level of appetite, food intake, metabolic hormones, basal metabolic rate and adiposity in normal and short stature children

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Ahmed Naseem Afzaal , Qayyum Mazhar , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Rafi Muhammad , Raza Rizvi Syed Shakeel

The acceleration in linear growth at puberty is attributed to the combined physiological effects of both somatotropic and gonadal axes. In synergy, growth hormone (GH) and gonadal steroids (testosterone (T) and estradiol (E2)) stimulate longitudinal bone growth through direct stimulation of chondrocytes and osteoblast. Nutrition such as sufficient amount of nutrients including calcium, phosphate, sodium, potassium and iron and vitamins like vitamin D, vitamin A and vitamin C p...

ea0070aep822 | Reproductive and Developmental Endocrinology | ECE2020

An assessment of the level of physiological stress in terms of release of cortisol, epinephrine, norepinephrine, prolactin and growth hormone and their relationship with ghrelin in normal and short stature children

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Ahmed Naseem Afzaal , Qayyum Mazhar , Tahir Faheem , Jahan Sarwat , Afshan Kiran , Rafi Muhammad , Shakeel Raza Rizvi Syed

The short children have lower social competence and show more social problems than children with normal stature. The physical appearance has consequences in terms of how short stature children are judged and treated by others as they can be teased or bullied due to short stature, which may affect future prospects of finding a job or a spouse. These psychosocial stressors are risk factors for the psychological adjustment for children of short stature. Stress responses are activ...

ea0073oc4.5 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2021

Lower level of sexual maturation rating and reduced concentrations of reproductive hormones, luteinizing hormone, follicle stimulating hormone, testosterone and estradiol in short stature children with mutations in growth hormone secretagogue receptor 1a

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Qayyum Mazhar , Naseem Afzaal Ahmed , Tahir Fahim , Jahan Sarwat , KiranAfshan , Rafi Muhammad , Raza Rizvi Syed Shakeel

Puberty onset is sensitive to the energy reserves of the organism, especially in females where there is an association between obesity and early puberty. Studies have shown that in the presence of growth hormone secretagogue receptor 1a (GHSR1a) mutations, there is a decrease in ghrelin-mediated appetite, resulting in relatively low BMI, which contributes to the delayed onset of puberty. Furthermore, delayed puberty is observed in clinical conditions associated with low IGF1, ...

ea0063p1160 | Thyroid 3 | ECE2019

Stress induced cortisol release depresses the secretion of triiodothyronine in patients with anterior wall myocardial infarction

Javid Muhammad , Kayani Amjad Rashid , Akram Maleeha , Kazmi Ali Raza , Jahan Sarwat , Afshan Kiran , Rauf Sania , Naseem Afzaal Ahmed , Tahir Fahim , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Stress is any uncomfortable emotional experience accompanied by predictable psychological, physiological and behavioral changes. A sudden and severe stress generally produces an increase in the heart rate and blood pressure and induces a state of alertness in an individual. Evidence indicates that chronic stress depresses thyroid function, resulting in low levels of T3 and T4, which affects cardiomyocytesÂ’ function and leads to development of cardiov...