Searchable abstracts of presentations at key conferences in endocrinology

ea0086p185 | Bone and Calcium | SFEBES2022

Finding the Culprit: A Rare Case of Oncogenic Osteomalacia

Rahim Haaris , Halim Sandra , Mulla Kaenat , Avari Parizad , Freudenthal Bernard , Comninos Alexander , Cox Jeremy

Oncogenic ostemalacia is a rare paraneoplastic syndrome characterised by renal phosphate wasting secondary to secretion of FGF-23 from mesenchymal tumours. Localisation of the tumour is wanted, as resection can lead to complete clinical and biochemical cure. We present a case of a 57 year old woman with a background of Vitamin D deficiency and secondary hyperparathyroidism, who presented with severe generalised aches and pain, worst in her ribs and thighs, such that she could ...

ea0086p37 | Bone and Calcium | SFEBES2022

The management of autosomal dominant hypoparathyroidism with CaSR mutation in pregnancy and breastfeeding

Halim Sandra , Rahim Haaris , Avari Parizad , Mulla Kaenat , Freudenthal Bernard , N Comninos Alexander , Agha-Jaffar Rochan , Robinson Stephen , Cox Jeremy

Autosomal dominant hypoparathyroidism (ADH) is caused by gain-of-function mutations in the calcium-sensing receptor (CaSR), increasing its sensitivity to extracellular calcium, suppressing PTH and resulting in hypocalcaemia. In contrast to idiopathic hypoparathyroidism, treatment to correct serum calcium results in high urine calcium excretion, causing nephrocalcinosis, stones and renal impairment. Unlike surgical hypoparathyroidism where calcium should be maintained, patients...