Searchable abstracts of presentations at key conferences in endocrinology

ea0039ep83 | Miscellaneous/other | BSPED2015

Determination of pancreatic hormones in children with different forms of hyperinsulinaemic hypoglycaemia

Guemes Maria , Morgan Kate , Gilbert Clare , Rahman Sofia , Hussain Khalid

Introduction: In congenital hyperinsulinism (CHI) hypoglycaemia results from a dysregulation of insulin secretion. We hypothesised that other pancreatic hormones may also be dysregulated in this condition.Objectives: To proof the applicability of Luminex Multiplex method to measure pancreatic hormones (insulin, C-peptide, glucagon, amylin and PP) in the paediatric age. To elucidate the fasting response of these hormones in children with different forms o...

ea0036oc4.6 | Oral Communications 4 | BSPED2014

Evaluating dipeptidyl peptidase-4 expression in patients with diffuse and focal congenital hyperinsulinism.

Rahman Sofia A , Sherif Maha M A , Tahir Sophia , Hussain Khalid

Background: Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia and is due to the unregulated secretion of insulin from the pancreatic beta-cells. The role of gut hormones and dipeptidyl peptidase-4 (DPP-4) is currently unknown in patients with CHI.Aims: To evaluate the expression pattern of DPP-4 in focal and diffuse CHI.Method: Using intra-operative formalin-fixed paraffin embedded (FFPE) pancreati...

ea0045p70 | Pituitary and growth | BSPED2016

A mutation in eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) associated with a novel syndrome of X-linked hypopituitarism and glucose dysregulation

Gregory Louise , Ferreira Carolina , Williams Hywel , Rahman Sofia , Alatzoglou Kyriaki , Kapoor Ritika , Jones Peter , Hussain Khalid , Gaston-Massuet Carles , Qasim Waseem , Dattani Mehul

Background: EIF2S3 (NM_001415; Xp22.11) mutations have previously been reported in a single pedigree with microcephaly and developmental delay. The gene encodes the eukaryotic translation initiation factor 2 subunit 3 (eIF2γ), the largest of three EIF2 subunits. EIF2 is a heterotrimeric GTP-binding protein, which initiates protein synthesis. It forms a ternary complex, mediating recruitment of initiator methionyl-tRNA to the 40S ribosomal subunit to scan the mRNA...

ea0039p4 | (1) | BSPED2015

Use of long acting somatostatin analogue (Lanreotide) in CHI – its pharmacokinetics and long-term follow-up study

Shah Pratik , Rahman Sofia , McElroy Sharon , Gilbert Clare , Morgan Kate , Hinchey Louise , Button Roberta , Margetts Rebecca , Senniappan Senthil , Guemes Maria , Levy Hannah , Morte Marti Carles , Celma Lezcano Carles , Amin Rakesh , Hussain Khalid

Background: CHI is a cause of severe hypoglycaemia in children. Diazoxide (KATP channel agonist) is used as first-line treatment but is known to cause severe hypertrichosis and reduced appetite in children. Diazoxide unresponsive CHI us treated with daily octreotide subcutaneous injections (3–4 times/day).Objective and hypotheses: To evaluate the efficacy, safety and pharmacokinetics of long acting Somatostatin analogue (Lanreotide) thera...