Searchable abstracts of presentations at key conferences in endocrinology

ea0058p009 | Bone | BSPED2018

A case of persistent hypercalcaemia, following accidental denosumab administration

Paltoglou George , Brain Caroline , Amin Rakesh , Durani Sina , Rajamoorthy Vidhooshni , Esther Freeman , Braha Nirit , De Keyser Paul , Calder Alistair , Allgrove Jeremy

Introduction: Denosumab, a human monoclonal antibody that inhibits activation of osteoclasts provides sustained suppression of bone turnover in osteolytic bone disease. Denosumab has rarely been associated with late hypercalcaemia following therapeutic administration for bone tumours in children, bone metastases in adults and in children with Osteogenesis Imperfecta Type VI.Case report: A male child of Indian origin was referred for advice to GOSH from a...