Endocrine Abstracts

Introduction: Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease, that is characterised by painful lesions in apocrine gland-bearing areas. Patients also present with significantly increased rates of cardiovascular risk factors, such as dyslipidaemia, diabetes, metabolic syndrome. Adalimumab a fully human IgG1 monoclonal antibody that specifically binds to TNF-α is an established treatment for HS. Combined hormonal contraception is commo...

Introduction: Somapacitan is 23.3-kDa human GH derivate linked to small noncovalent albumin binding moiety that facilitates reversible endogenous albumin binding to delay somapacitan elimination. The longer half-life and improved pharmacodynamics allow injections once per week. Some patients find a daily regimen with established treatment difficult, especially because treatment may be lifelong or at least for several years. Poor adherence with medication can lead to poorer cli...

Introduction: An 80-year old female with known osteoporosis was reassessed for BMD measurement. Her baseline BMD and T-score of lumbar spine (L1–L4) measured in 2004 were 0.699 g/cm2, −3.5 S.D., T-score of total left hip was 0.618 g/cm2, −2.7 S.D.. She was treated with alendronate 70 mg, cholecalciferol 7000 IE per week and calcium supplements.Case report: At follow-up...

Objective: Bone strength post heart transplant (HT) is affected by many factors including glucocorticoids, calcineurin inhibitors, hypogonadism, vitamin D deficiency, secondary hyperparathyroidism and cachexia. Trabecular bone score (TBS), novel texture index derived from lumbar spinal DXA improves fracture risk assessment in several different high-risk populations, whereas it remains largely understudied in HT recipients. We aimed to evaluate factors that affect TBS after HT....

Objective: Trabecular bone score (TBS) is associated with an increased risk of prevalent and incident fractures. It has a role of fracture assessment in secondary osteoporosis related to diabetes, acromegaly and hyperparathyroidism and in glucocorticoid-induced osteoporosis. However, it is understudied as a marker of bone health in heart transplanted patients. The aim of our pilot study was to evaluate the effects of zoledronic acid (ZA) on bone health including TBS in this po...

Introduction: Growing evidences imply a role of coagulation system in the development of thromboembolic events and progression of atherosclerosis in PCOS. The aim of the study was to identify potential relationship of overall haemostatic potential (OHP) with a syndrome per se, BMI and androgens. OHP has not yet been assessed in PCOS.Methods: In 89 women with PCOS aged 30.9±8.1 years (50 obese, 13 overweight, and 27 normal weight) and 21 hea...

Background: Pituitary apoplexy (PA) is a rare, potentially life-threatening endocrine emergency, due to abrupt pituitary haemorrhage and/or infarction, usually within a pituitary adenoma. PA most commonly presents with severe headache, visual and oculomotor activity disturbances, nausea/vomiting and/or altered mental status. The outcome is variable and difficult to predict. Most proposed risk factors are hypertension (HTN), diabetes mellitus (DM), and anticoagulant treatment. ...

Objective: During the current pandemic of COVID-19, many therapeutic protocols adopted high dose systemic glucocorticoids (GC) for treatment of moderate to severe respiratory insufficiency. The suppression of the hypothalamic–pituitary–adrenal axis by synthetic GC, even after a short treatment period, cannot be reliably predicted due to pathophysiological changes in cortisol dynamics in critically ill, inter-individual pharmacokinetic differences, and sensitivity var...

Background: Pheochromocytomas (PHEO) and paragangliomas (PGL) are rare neuroendocrine tumors that can lead to life-threatening conditions. The diagnosis of PHEO/PGL is established by measuring normetanephrine and metanephrine. Biochemical detection usually precedes clinical diagnosis of PHEO/PGL by several years. Co-occurrence of cyanotic congenital heart disease (CCHD) and PHEO/PGL has been reported but potential association remains unclear. We aimed to compare plasma metanep...

Background: Spinal muscular atrophy (SMA) is hereditary, degenerative, neuro-muscular disease of lower motor neurone that leads to muscle weakness and atrophy. Several metabolic disturbances such as impaired glucose tolerance (IGT), insulin resistance (IR), hypoglycaemia and dyslipidaemia can be present. Most studies were done in children, with more severe forms of SMA. We aimed to assess body composition, IR, glucose and lipid metabolism in adult patients with SMA type 2 and ...