Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1135 | Endocrine tumours | ECE2015

Genotype-phenotype correlations in a series of patients with von Hippel-Lindau disease in one single tertiary centre

Furnica Raluca Maria , Janin Nicolas , Maiter Dominique

Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumour syndrome with an important phenotypic variability. Genetic testing for VHL is simple and accurate.Objective: In this study, we investigated the relationships between genotype and phenotype in a series of patients with different VHL gene mutations.Method: This was a retrospective analysis of the clinical and molecular characteristics of 15 VHL pati...

ea0090p391 | Endocrine-related Cancer | ECE2023

Urinary free cortisol is an independent predictive factor for early distinction between ectopic ACTH secretion and pituitary Cushing’s disease

Raluca Furnica , Collard Alix , Frank Cornelis , Alexopoulou Orsalia , Maiter Dominique

Introduction: The poor prognosis of patients with Cushing’s syndrome due to ectopic ACTH secretion (ECS) requires prompt diagnosis and management of the disease. Objectives: To find clinical and biological differences between ECS and pituitary Cushing’s disease (CD) at diagnosis and to determine whether any of them may be a potential predictor for early suspicion of ECS. Methods: This was a retrospective case-nested study...

ea0090p688 | Pituitary and Neuroendocrinology | ECE2023

Incidental pituitary macroadenoma: natural history and surgical results

Matei Constantinescu Stefan , Alexopoulou Orsalia , Duprez Thierry , Furnica Raluca , Fomekong Edward , Raftopoulos Christian , Maiter Dominique

Introduction: The Incidental diagnosis of non-functioning pituitary macroadenomas (NPFMA) is becoming more prevalent with the spread of modern imaging techniques. More clinical data about their natural history and surgical results are needed. Methods: We retrospectively analyzed medical files of patients referred to our clinic for an incidental NFPMA between 2010 and 2019. In particular, we compared patients that experienced tumor growth or not during su...

ea0037gp.28.08 | Endocrine tumours and neoplasia – NETS | ECE2015

General characteristics and evaluation of β-cell function and insulin sensitivity in a large monocentric series of insulinomas

Furnica Raluca Maria , Istasse Laure , Gigot Jean-Francois , Deprez Pierre , Buysschaert Martin , Maiter Dominique

Background: Insulinomas are the most common functional neuroendocrine tumours of the pancreas. Hypoglycaemic manifestations are highly variable and largely independent on tumour size and severity of insulin hypersecretion.Objectives: In this study we investigated the clinical, biological and tumoural characteristics of a large series of patients with insulinoma and we evaluated the sensitivity of peripheral tissues to insulin before and after surgery.</p...

ea0071014 | Influence of catecholamine secretory phenotype and preoperative alpha-blocker preparation on surgical outcome in pheochromocytoma | BES2020

Influence of catecholamine secretory phenotype and preoperative alpha-blocker preparation on surgical outcome in pheochromocytoma

Maria Furnica Raluca , Muddaththir Dusoruth Muhammad , Damien Gruson , Alexandre Persu , Michel Mourad , Dominique Maiter

Objectives: Surgery of pheochromocytomas (PC) still carries a high risk of hemodynamic complications during the perioperative period. We aimed to evaluate the influence of their secretory phenotype and preoperative alpha-blocker treatment on surgical outcome.Design: A retrospective monocentric study at a tertiary medical center.Patients: 80 consecutive patients operated for an adrenal PC between 1988 and 2018.<p class="abstext"...