ea0011p385 | Diabetes, metabolism and cardiovascular | ECE2006
Man TY
, Ramage L
, Gokcel A
, Michailidou Z
, Kenyon CJ
, Chapman K
, Seckl JR
, Morton NM
Obesity/Metabolic syndrome (insulin resistance, hypertension, cardiovascular disease) has reached epidemic levels in western societies. Aberrantly elevated glucocorticoid amplification by intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) within adipose tissue might explain the striking similarities between idiopathic obesity/metabolic syndrome and Cushings syndrome, causes by plasma GC excess. A major contributor to obesity/metabol...