Searchable abstracts of presentations at key conferences in endocrinology

ea0090p433 | Pituitary and Neuroendocrinology | ECE2023

Lanreotide-Induced Acalculous Acute Pancreatitis in a Person with Acromegaly: an Unexpected Severe Side Effect

Ramalho Diogo , Alves Helena , Henrique Carmona Alexandrino Jorge , Jesus Nuno , Melo Gustavo , Joao Oliveira Maria

Introduction: Somatostatin analogues (SA) are the first-line treatment for Acromegaly in patients whose surgery failed to achieve cure or it was contraindicated. The main reported adverse events of SA are mild and transient, and include nausea, abdominal cramps, diarrhea and flatulence. Other side effects are of rare occurrence.Case report: The authors describe a case of a 44-year-old previously asymptomatic male patient with a growth hormone-secreting p...

ea0070ep308 | Pituitary and Neuroendocrinology | ECE2020

Insipidus diabetes and vaginal ulcers... evidence for the diagnosis of langerhans cell hypophysitis

Correia Sara , Melo Gustavo , Alves Helena , Almeida Lucia , João Oliveira Maria , Ramalho Diogo

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...

ea0073pep14.1 | Presented ePosters 14: COVID-19 | ECE2021

Is initial hypocalcemia related to poorer outcomes in COVID-19 patients?

Alves Helena , Ferreira Marta Almeida , Almeida Lucia , Correia Sara , Ramalho Diogo , João Oliveira Maria

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

ea0073aep48 | Adrenal and Cardiovascular Endocrinology | ECE2021

Lipid paradox in acute myocardial infarction

Correia Sara , Ramalho Diogo , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

ea0073aep168 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use of the thrombolysis in myocardial infarction risk score for heart failure in diabetes in a type 2 diabetes mellitus outpatient population

Ramalho Diogo , Correia Sara , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...

ea0092ps3-22-09 | Nodules 2 | ETA2023

Percutaneous ethanol sclerotherapy for the treatment of benign cystic thyroid nodules: A 5 year-experience at a tertiary care hospital

Carmona Alexandrino Henrique , Ramalho Diogo , Machado Catarina , Jesus Nuno , Ferreira Marta , Rocha Gustavo , Joao Oliveira Maria

Objectives: Assess the efficacy and safety of ultrasound-guided percutaneous ethanol injection (PEI) for treating benign cystic or predominantly cystic-thyroid nodules (TN).Methods: Retrospective analysis of all euthyroid patients treated with PEI for purely (>90% of cystic component) or predominantly cystic (50%-90% of cystic component) TN between January 2018 to February 2023. Efficacy was defined as 50% or greater reduction in pretreatment volume ...

ea0081p399 | Pituitary and Neuroendocrinology | ECE2022

Familial neurohypophyseal diabetes insipidus: an extremely rare report of a family with a nonsense mutation in the arginine vasopressin gene

Ramalho Diogo , Serra-Caetano Joana , Cardoso Rita , Rosinha Patricia , Filipa Araujo Barbara , Rua Ines , Rodrigues Orlando , Dinis Isabel , Mirante Alice

Introduction: Familial neurohypophyseal diabetes insipidus (FNDI) is a rare form of central diabetes insipidus (CDI) characterized by childhood-onset progressive polydipsia and polyuria due to mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene.Case description: Two male siblings were referred at 1 month of age to exclude CDI owing to a family history of CDI in the father and paternal grandfather. The proband was the fa...

ea0084ps2-06-55 | Hypothyroidism Treatment | ETA2022

Free T3 levels and clinical status of patients with levothyroxine-compensated primary hypothyroidism: can we do better?

Ramalho Diogo , Almeida Lucia , Ferreira Marta , Correia Sara , Alves Helena , Carmona Henrique , Rocha Gustavo , Joao Oliveira Maria

Objectives: To evaluate the relationship between free T3 (FT3) levels with symptoms suggestive of thyroid dysfunction, and quality of life (QoL) outcomes, in patients with compensated primary hypothyroidism (PH).Methods: Cross-sectional study encompassing Portuguese levothyroxine(LT4)-treated patients for PH who presented Thyroid-stimulating hormone (TSH) and free T4 (FT4) within the normal range. Pregnant women, patients with central hypothyroidism and/...

ea0070ep176 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic ketoacidosis and continuous glucose monitoring – a case report

Ramalho Diogo , Rocha Gustavo , Alves Helena , Correia Sara , Almeida Lúcia , João Oliveira Maria

Introduction: Diabetic ketoacidosis (DKA) is characterized by the triad – ketonemia, metabolic acidosis and hyperglycemia. It is typically associated with type 1 Diabetes Mellitus (T1D) and the most common culprits are infections and poor therapeutic compliance.Clinical Case DescriptionThe present case deals with a 25–year–old female patient, with T1D diagnosed in 2008, without microvascular or macrovascular compl...

ea0070ep477 | Thyroid | ECE2020

Thyrotoxicosis and Tuberculosis (TB) related cervical lymphadenopathies: A case report

Almeida Lucia , Sousa Ana , Melo Gustavo , Ramalho Diogo , Correia Sara , Alves Helena , João Oliveira Maria

Introduction: Grave´s disease (GD) is the most prevalent cause of hyperthyroidism, leading to inflammation of the thyroid gland and sometimes to an enlargement of the nearest lymph nodes caused by that same inflammatory process. Peripheral lymphadenopathy of doubtful cause presents a diagnostic dilemma. There are many potential causes: biopsy is sometimes the best way to reach a definitive diagnosis. Tuberculous adenitis is usually regional and mainly affects nodes of the...