Searchable abstracts of presentations at key conferences in endocrinology

ea0032p690 | Neuroendocrinology | ECE2013

Iron overload impairs the migratory ability of a model of immature and migratory GnRH neurons

Steffani Liliana , Nitto Francesca Di , Macchi Chiara , Dongiovanni Paola , Rametta Raffaella , Valenti Luca Vittorio , Fargion Silvia , Magni Paolo , Ruscica Massimiliano

Iron represents a micronutrient for cellular metabolism and aerobic respiration, and is essential for proper brain development in the fetal and early neonatal period. However, excess iron produces toxic build-up via free radical formation. In thalassaemic and juvenile hemochromatosis patients with pubertal failure, iron overload interferes with the correct function of the hypothalamic–pituitary axis, leading to hypogonadotrophic hypogonadism and growth failure, but the me...