ea0063p664 | Interdisciplinary Endocrinology 1 | ECE2019
Nikolaou Nikolaos
, Morgan Stuart
, Larner Dean
, Sharp Anna
, Raouf Zachariah
, Hughes Beverly
, Digweed Dena
, Whitaker Martin
, Ross Richard
, Lavery Gareth
, Arlt Wiebke
, Gathercole Laura
, Tomlinson Jeremy
The prevalence of metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), continues to escalate. Glucocorticoids (GCs) and bile acids (BAs) are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human and rodent liver, where it inactivates steroid hormones and catalyses a fundamental step in BA synthesis. We have previously demonstrated that AKR1D1 modulates hepatic GC availability and GC recept...