Endocrine Abstracts

Case history: A previous healthy 69 year-old female was brought into the ED by her worried husband after he noticed worsening confusion. She developed seizures post arrival to the ED and was admitted under ITU for further care. Retrospective history from the husband indicated she had started feeling unwell around Christmas with a feeling of malaise. She self-medicated with amoxicillin which she had access to as a nurse practitioner. Over the next 2 days she developed headaches...

Autosomal Dominant Hypocalcaemia (ADH) type 1 is caused by activating mutations of the calcium-sensing receptor (CaSR) gene. Although a rare condition, the exact prevalence is uncertain as patients are asymptomatic and, historically, were sometimes diagnosed with hypoparathyroidism (HPT) due insensitivity of earlier PTH assays and failure to check urinary calcium. The consequences of an erroneous diagnosis of HPT in patients with ADH can be profound, as treatment with calcium ...

Background: The COVID-19 pandemic has resulted in widespread disruption to delivery of emergency and elective care in the last 2 years. Nevertheless, healthcare systems have quickly readapted to accelerate use of novel pathways for delivering clinical services. We reviewed the impact of COVID-19 pandemic on our time from community referral to definitive surgery in patients with Primary Hyperparathyroidism (PHPT).Methods: We retrospectively reviewed the w...

Background: Prevalence of Addison’s disease (AD) among patients with Type 1 diabetes mellitus (T1DM) is estimated at 0.2%, whilst prevalence of T1DM among patients with AD can be up to 14%. Residual adrenal function in patients with established AD may be present in up to 30% of cases but its clinical significance is not fully clear.Aims: To evaluate the prevalence of AD with preserved glucocorticoid function in patients with T1DM at Newcastle Diabet...

Background: Cushing’s disease (CD) is rare, and standard treatment is trans-sphenoidal surgery (TSS). We previously reported a remission rate of 56% in patients undergoing TSS for CD from a microadenoma/normal pituitary on MR in our unit. Early post-operative hypocortisolaemia performs well at predicting durable remission early on. Post-operative day 1 cortisol of <55 nmol/l has a 100% sensitivity and <138 nmol/l 95% sensitivity at predicting remission. Since Octo...