ea0007p60 | Diabetes, metabolism and cardiovascular | BES2004
Wake D
, Elferink C
, Rask E
, Westerbacka J
, Livingstone D
, Soderberg S
, Yki-Jarvinen H
, Olsson T
, Andrew R
, Walker B
Intra-adipose steroid metabolism may be a key determinant of accumulation and distribution of body fat. Adverse 'central' fat can be driven by glucocorticoid excess or decreased oestrogen/androgen ratio. We previously demonstrated increased regeneration of cortisol by 11beta-HSD1 in adipose in human obesity. Here, we measured mRNAs for enzymes dictating local activation of oestrogens (aromatase) and androgens (5alpha-reductase type 1) in subcutaneous human adipose and related ...