Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep46 | Adrenal cortex | ECE2015

Adrenal insufficiency during prednisolone treatment: need for cortisol replacement strategies in patients on long-term low-dose glucocorticoid treatment?

Borresen Stina Willemoes , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Background: Patients on long-term glucocorticoid treatment are at risk of adrenal insufficiency during glucocorticoid treatment. The side effect can occur during glucocorticoid treatment if there is a mismatch between glucocorticoid requirements and production/intake. High-dose glucocorticoid treatment is often sufficient to overcome most stressful situations. A low-dose of 5 mg prednisolone/day is however, equivalent to 20 mg hydrocortisone, a dose often used as basal glucoco...

ea0035p35 | Adrenal cortex | ECE2014

Glucocorticoid-induced adrenal insufficiency in prednisolone treated patients and how it relates to glucocorticoid dose and the duration of treatment

Dinsen Stina , Baslund Bo , Klose Marianne , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hilsted Linda , Locht Henning , Hansen Annette , Feldt-Rasmussen Ulla

Objective: We aimed to assess the prevalence of glucocorticoid-induced adrenal insufficiency in prednisolone treated patients, and its relation to glucocorticoid dose and duration of treatment.Subjects and measures: As part of a larger study 48 patients with rheumatoid arthritis (33 women, aged 34–85 years) treated with a mean prednisolone dose of 7.0 mg (range 5–20 mg) per day, and a mean duration of treatment of 95 months (range: 6–360 m...

ea0035p513 | Endocrine disruptors | ECE2014

Di-ethylhexyl-phthalate is metabolised by human thyroid cells and may influence thyroglobulin secretion

Hansen Juliana Frohnert , Brorson Marianne Moller , Hartoft-Nielsen Marie-Louise , Boas Malene , Main Katharina M , Frederiksen Hanne , Hofman-Bang Jacob , Rasmussen AEse Krogh , Feldt-Rasmussen Ulla

Introduction: Phthalates are suspected to influence thyroid function in epidemiologic and experimental animal studies. The aim of the study was to investigate the ability of primary human thyroid cell cultures to metabolise phthalates and a possible concentration-dependent response of phthalates on thyroglobulin (Tg) secretion.Methods: Human thyrocytes obtained from thyroidectomies were cultured to confluent monolayers. These were exposed to DEHP in conc...

ea0056gp44 | Adrenal medulla and NETs | ECE2018

Mortality in patients with Pheochromocytoma: a population-based study 1977–2016

Ebbehoj Andreas Ladefoged , Sondergaard Esben , Jacobsen Sarah Forslund , Trolle Christian , Robaczyk Maciej Grzegorz , Rasmussen AEse Krogh , Feldt-Rasmussen Ulla , Thomsen Reimar Wernich , Stochholm Kirstine , Poulsen Per Logstrup

Background: Pheochromocytomas and catecholamine-secreting paragangliomas (PPGL) are rare catecholamine-producing tumors. Due to the rarity, limited data on prognosis exists and data are mainly from tertiary centers with potential referral bias. Here, we present population-based mortality data over an observation period of 40 years.Materials and methods: We identified a cohort of 198 PPGL patients diagnosed 1 January 1977 to 31 December 2016 in North and ...

ea0056p1082 | Thyroid (non-cancer) | ECE2018

How should thyroid-related quality of life be assessed? Standard recall measures compared with here-and-now measures

Boesen Victor Brun , Feldt-Rasmussen Ulla , Bjorner Jakob Bue , Cramon Per , Gronvold Mogens , Nygaard Birte , Rasmussen AEse Krogh , Vilsboll Tina , Watt Torquil

Introduction: Some methodologists have raised concern about the validity of the standard method of assessing patient-reported outcomes, i.e. retrospective questionnaires. Repeated momentary measurements have been introduced to avoid recall bias and provide ecological validity. Although having theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported ...

ea0049ep40 | Adrenal cortex (to include Cushing's) | ECE2017

Predictive baseline morning P-cortisol levels for the response to a Synacthen test in prednisolone treated patients

Borresen Stina Willemoes , Klose Marianne , Locht Henning , Laursen Toke , Jensen Bente , Hilsted Linda , Baslund Bo , Rasmussen AEse Krogh , Friis-Hansen Lennart , Hansen Annette , Hetland Merete Lund , Feldt-Rasmussen Ulla

Introduction: Evaluation of glucocorticoid production generally requires a dynamic test. Cut-off levels for baseline cortisol concentrations predicting the outcome of a Synacthen test have been proposed for different cortisol assays. With introduction of the new Roche Elecsys Cortisol II assay, P-cortisol concentrations are expected to decrease by 20%. We have investigated cut-off levels for baseline P-cortisol concentrations measured with the Roche Elecsys Cortisol II assay t...

ea0056p1056 | Thyroid (non-cancer) | ECE2018

Adaptation and cross-cultural validation of the Spanish version of the Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire

Gonzalez Lleo Ana Maria , Cortes Mauro Boronat , Feldt-Rasmussen Ulla , Perez Carlos Rodriguez , Rasmussen AEse Krogh , Plasencia Yaiza Lopez , Hegedus Laszlo , del Pino Alberiche Ruano Maria , Bonnema Steen Joop , Arencibia Dunia Marrero , Groenvold Mogens , Bjorner Jakob Bue , Watt Torquil

Introduction: The thyroid-related quality-of-life patient-reported outcome ThyPRO questionnaire is the most widely used tool for measuring health-related quality of life (QoL) in patients with benign thyroid diseases. The aim of this study was to adapt and validate a Spanish version of the ThyPRO.Methods: The ThyPRO consists of 85 items, grouped in 13 scales and one single QoL item. Scales cover physical and mental symptoms, well-being and function, soci...