ea0065ec1.1 | Early Career Prize Lecture Basic Science | SFEBES2019
Cebola Ines
, Miguel-Escalada Irene
, Bonas-Guarch Silvia
, Ponsa-Cobas Joan
, Atla Goutham
, Javierre Biola
, Ravassard Philippe
, Fraser Peter
, Ferrer Jorge
Genome-wide association studies have identified nearly 250 loci carrying genetic variants associated with type 2 diabetes (T2D) susceptibility, which are often located within pancreatic islet transcriptional enhancers. Due to the complex nature of transcriptional enhancers, assigning risk variants to true disease susceptibility effector genes has remained a challenge. In this study, we applied promoter capture Hi-C to create a genome-wide map of promoter-enhancer interactions ...