Endocrine Abstracts

A 36-year-old woman was admitted with newly diagnosed Grave’s disease due to significant symptoms. Blood results revealed fT4 83.2 (pmol/l) TSH <0.01 (mIU/l), and TSH Receptor Antibody 4.56 (0-0.4 U/l)). She was commenced on Propylthiouracil (PTU) thrice daily alongside Propranolol. She had a blood test in 4 months’ time, when she was 5 weeks pregnant. Blood results suggested profound hypothyroidism with fT4 4.7 (pmol/l) and TSH 82.02 (mIU/l), and she was commenc...

Hashimoto’s thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas of the world, cause is thought to be a combination of genetic susceptibility and environmental factors. The pathology of the disease involves the formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis. We present the case of a 38 year old male with history of hypertension, type 2 Diabetes and pre-existing hypothyroidism who presented with...

Coexistence of primary hyperparathyroidism and multiple myeloma is very rare.Case report: 45 year old Jamaican female presented with left sided chest pain for a month. CXR showed a pathological left clavicular fracture with a lytic lesion. She was noted to have a serum Ca of 3.26 mmol/l.Other investigations: Haemoglobin 115 g/l (115–155), creatinine 76 umol/l (49–92), Corrected Ca 3.26 mmol/l (2.20–2.60), Phosphate 0...

Introduction: Coexistence of primary hyperparathyroidism and plasma cell dyscrasias such as multiple myeloma and monoclonal gammopathy of uncertain significance (MGUS) is rare. This can cause diagnostic uncertainty regarding the aetiology and relative contribution of each disorder to hypercalcaemia. We present a series of five individuals with this combination.Case series: All five patients were referred to the endocrine clinic with hypercalcaemia. The s...

Background: Primary hyperparathyroidism is the third most common endocrine condition in pregnancy after thyroid disease and diabetes. Untreated hypercalcaemia due to primary hyperparathyroidism increases the risk of miscarriage, intrauterine death and preterm labour. Pharmacological and surgical limitations in pregnancy often make diagnosing and managing this condition challenging. We report a complex case of hypercalcaemia-induced -psychosis due to primary hyperparathyroidism...