Searchable abstracts of presentations at key conferences in endocrinology

ea0051s1.3 | Endocrine Track 1: Symposium 1 | BSPED2017

Subclinical hypothyroidism – lessons from clinical studies in adults

Razvi Salman

Subclinical hypothyroidism (SCH) is a relatively common endocrine condition characterised by raised serum thyrotropin (TSH) levels in the presence of normal circulating thyroid hormones. It is generally recognised that SCH – especially if it is sustained - is a mild form of hypothyroidism but whether it should be treated or not is a matter of a long-standing debate amongst both paediatric as well as adult endocrinologists. In adults, there are conflicting data on the long...

ea0063s6.3 | A better life with thyroid hormone (Endorsed by the European Journal of Endocrinology) | ECE2019

Subclinical hypothyroidism in the elderly

Razvi Salman

Background: Both overt hypothyroidism as well as subclinical hypothyroidism is frequently encountered in older individuals. It is increasingly being recognised that treatment of subclinical hypothyroidism may not be beneficial, particularly in an older person. These findings are particularly relevant at a time when treatment with thyroid hormones is increasing and more than 10–15% of people aged over 80 years are prescribed levothyroxine therapy.Mai...

ea0044p247 | Thyroid | SFEBES2016

Aiming for a serum TSH in the higher reference range in older levothyroxine treated hypothyroid individuals – a randomized controlled proof of concept trial (SORTED 1)

Razvi Salman

Context: Serum TSH reference range increases with age but target TSH is similar in younger and older hypothyroid patients on treatment. It is unknown if quality of life (QoL), hypothyroid symptoms and cardiovascular (CV) risk factors change in older patients in whom a higher serum TSH is aimed for.Objective: To assess if a higher target serum TSH of 4.01–8.0 mU/l is feasible in and acceptable to older treated hypothyroid patients.<p class="abste...

ea0034p422 | Thyroid | SFEBES2014

Neutrophil phagocytic capacity is lower in patients with abnormal thyroid function in critical illness

Browne Emma , Simpson John , Razvi Salman

Background: Thyroid function is affected by critical illness – termed as non-thyroidal illness – and usually presents with low serum TSH and FT3 levels but normal FT3 concentrations. Critically ill patients may also have impaired immune function that could contribute to increased susceptibility to acquired infections and mortality. Thyroid hormones influence neutrophil levels and function but the effect of non-thyroidal illness on neutrophil fun...

ea0028p351 | Thyroid | SFEBES2012

TBII at discontinuation of ATD therapy as a predictor of relapse of hyperthyroidism in Graves’ disease - a prospective analysis

Stewart Kathryn , Handley Graham , Razvi Salman

Background: Graves’ hyperthyroidism is treated with anti-thyroid drugs (ATD) for 12–18 months, after which ~50% of patients remain euthyroid. Risk factors predicting relapse are: male gender, younger age, orbitopathy, large goitres, severe hyperthyroidism at diagnosis and smoking. Recent reports suggest measurement of TBII at ATD cessation is useful in predicting risk of relapse. Aim: To prospectively investigate whether TBII levels at cessation of ATD therapy are us...

ea0025p324 | Thyroid | SFEBES2011

Effect of weight loss through gastric bypass on thyroid function in euthyroid people with morbid obesity

MacCuish Antonia , Razvi Salman , Syed Akheel

Background: Thyroid function within the normal range has been shown to influence body weight in a population. Even slightly elevated serum TSH levels are associated with an increase in the occurrence of obesity. It is unclear whether significant weight loss has the reverse effect on thyroid function, and studies to date have yielded inconsistent results.Aims: Our aim was to describe changes in TSH and fT4 in relation to durable and significant...

ea0025p337 | Thyroid | SFEBES2011

Seasonal variation in thyroid autoimmunity as assessed by anti-thyroid peroxidase antibodies is related to temperature

Middleton Gina , Barker John , Razvi Salman

Background: Environmental factors play a role in the pathogenesis of autoimmune conditions. The incidence of type 1 diabetes is higher in winter. It is unclear whether autoimmune thyroid disease is similarly affected by seasonal variation. We aimed to study the variation in anti thyroid peroxidase (TPO) antibodies in relation to calendar month of sampling.Methods: We obtained TPO-antibody results for the 12 months (October 2009 till September 2010). Indi...

ea0013p242 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Subclinical hypothyroidism is associated with increased cardiovascular risk: A meta-analysis

Razvi Salman , Weaver Jolanta , Pearce Simon

There are discrepancies between different studies with regards to the association of subclinical hypothyroidism (SCH), dyslipidaemia and cardiovascular (CV) disease. Therefore, we have conducted a systematic search and meta-analysis of population-based studies of CV disease in which thyroid status was examined and randomised controlled trials (RCTs) of treatment.The PubMed and Embase databases were searched for relevant studies published between 1976 and...

ea0050p386 | Thyroid | SFEBES2017

Prevalence of and factors predicting thyroid dysfunction at the time of ST- and non-ST- elevation myocardial infarction – the ThyrAMI 1 study

Jabbar Avais , Ingoe Lorna , Zaman Azfar , Razvi Salman

Introduction: Thyroid dysfunction is common affecting 5–10% of the adult population. Cardiovascular disease, including acute myocardial infarction (AMI), has been suggested as one of the adverse outcomes of thyroid disease. Furthermore, individuals with thyroid dysfunction at the time of AMI have worse outcomes. Despite this, there is scarce data on the prevalence of thyroid dysfunction in patients with AMI. We conducted a prospective observational multi-cen...

ea0050p392 | Thyroid | SFEBES2017

The relationship between free T4 and thyrotropin receptor antibodies is log-linear and negatively influenced by age and smoking in patients with Graves’ disease

Gan Earn H , Tsatlidis Vasileios , Kennedy David , Razvi Salman

Background: The third generation thyrotropin receptor antibodies (TRAb) assay has high sensitivity and specificity in diagnosing Graves’ disease (GD). Circulating levels of TRAbs predict the disease course of Graves’ orbitopathy (GO) and remission rates in GD. However, the relationship between TRAb and thyroxine (FT4) and the factors affecting their interaction are unclear.Method: A prospective cohort study was conducted to evalua...