Searchable abstracts of presentations at key conferences in endocrinology

ea0077p85 | Neuroendocrinology and Pituitary | SFEBES2021

Clinical presentation of 209 surgically operated non-functioning pituitary macroadenomas

Edwards Mared , Hayhurst Caroline , Mohamed Amr , Davies J Steve , Rees D Aled , Lansdown Andrew

Background: The clinical presentation of non-functioning pituitary adenomas (NFAs) can range from an incidental finding on imaging to pituitary hormone deficiencies and visual compromise.Objective: To assess the clinical presentation of patients who had undergone surgical resection of histologically proven NFAs.Methods: Patients presenting to the University Hospital of Wales, Cardiff, with non-functioning pituitary adenomas (histol...

ea0050p007 | Adrenal and Steroids | SFEBES2017

Salivary cortisol response to the short Synacthen® test provides a reliable alternative to serum measurement in the assessment of suspected hypoadrenalism

El-Farhan Nadia , Tennant Sarah , Lansdown Andrew , Evans Carol , Rees D Aled

Background: Serum total cortisol responses to the short Synacthen® test (SST) are used to confirm or refute a diagnosis of adrenal insufficiency. Salivary cortisol measurement offers a non-invasive alternative and has the potential advantage of evaluating free, bioavailable cortisol. However, reference ranges and its performance in the investigation of suspected hypoadrenalism (SH) have not been firmly established.Aims: 1....

ea0050p007 | Adrenal and Steroids | SFEBES2017

Salivary cortisol response to the short Synacthen® test provides a reliable alternative to serum measurement in the assessment of suspected hypoadrenalism

El-Farhan Nadia , Tennant Sarah , Lansdown Andrew , Evans Carol , Rees D Aled

Background: Serum total cortisol responses to the short Synacthen® test (SST) are used to confirm or refute a diagnosis of adrenal insufficiency. Salivary cortisol measurement offers a non-invasive alternative and has the potential advantage of evaluating free, bioavailable cortisol. However, reference ranges and its performance in the investigation of suspected hypoadrenalism (SH) have not been firmly established.Aims: 1....

ea0059p216 | Thyroid | SFEBES2018

Management of ‘Anomalous’ thyroid results

Souza Lezia D , Evans Carol , Lansdown Andrew , Rees D Aled , Premawardhana Lakdasa

Background/objectives: While patients are commonly referred to endocrinology with a low FT4 and normal TSH, there is no consistency in the management of these patients. The aim of this audit was to assess management of these patients including investigation, diagnosis and pharmacological intervention and compare to the current Association for Clinical Biochemistry guidelines.Methods: This was a retrospective audit studying 41 endocrine outpatients at Uni...

ea0025p334 | Thyroid | SFEBES2011

Depot specific differences in regulation of hyaluronan production of relevance to Graves’ orbitopathy

Zhang Lei , Grennan-Jones Fiona , Lane Carol , Rees D Aled , Dayan Colin , Ludgate Marian

Expansion of the orbital contents, by adipogenesis and hyaluronan (HA) overproduction, causes Graves orbitopathy (GO). Orbital HA is generated predominantly by hyaluronan synthase 2 (HAS2) whose transcription is positively regulated by pAkt in cell lines. GO is most frequently associated with Graves’ disease (GD) in which thyroid stimulating antibodies bind the TSH receptor (TSHR) increasing cAMP. Previous studies highlight a role for TSAB and ‘neutral’ TSHR ant...